SCHEMBL5768629

SCHEMBL5768629

O=C(O)c1nn(-c2ccc(Cl)cc2Cl)c(Oc2ccc(Cl)cn2)c1C(F)F

nearest known ligand 0.40

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.40
RPA1 P27694 1/20 0.39
ALDH1A1 P00352 1/20 0.39
MARS1 P56192 6/20 0.39
CNR2 P34972 6/20 0.38
CNR1 P21554 5/20 0.38
LTA4H P09960 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5769548 0.87 KDM4E (0.49) CNR2CNR1
SCHEMBL6766024 0.85 LMNA (0.46) LMNARPA1ALDH1A1MARS1CNR2
SCHEMBL5768706 0.72 KDM4E (0.52) CNR2CNR1
SCHEMBL6766465 0.69 CNR2 (0.59) CNR2CNR1
SCHEMBL6765998 0.67 CNR2 (0.45) CNR2CNR1
SCHEMBL7047587 0.67 LMNA (0.46) LMNARPA1ALDH1A1CNR2CNR1
SCHEMBL6765994 0.66 CNR1 (0.48) LMNAALDH1A1CNR2CNR1
SCHEMBL2946392 0.65 LMNA (0.47) LMNAMARS1CNR2CNR1
SCHEMBL13955259 0.65 LMNA (0.67) LMNARPA1ALDH1A1CNR2CNR1
SCHEMBL4453509 0.64 LMNA (0.48) LMNARPA1CNR2CNR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040235926-A1 Cannabinoid receptor ligands and uses thereof PFIZER INC. 2004-11-25 US claimed
EP-1622876-A1 CANNABINOID RECEPTOR LIGANDS AND USES THEREOF Pfizer Products Inc. (US) 2006-02-08 EP disclosed
US-20040235926-A1 Cannabinoid receptor ligands and uses thereof PFIZER INC. 2004-11-25 US disclosed
WO-2004099157-A1 CANNABINOID RECEPTOR LIGANDS AND USES THEREOF PFIZER PRODUCTS INC. (US) 2004-11-18 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040235926-A1 Cannabinoid receptor ligands and uses thereof CNR1, CNR2, GPR18 LMNA 3194/4885RPA1 4560/4885ALDH1A1 1547/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.