Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 3/20 | 0.36 |
| ▸ | JAK2 | O60674 | 2/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 7/20 | 0.36 |
| ▸ | CDK2 | P24941 | 7/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CCND1 | P24385 | 1/20 | 0.33 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6101777 | 0.83 | ALDH1A1 (0.44) | LMNAALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL6099917 | 0.77 | JAK1 (0.41) | LMNAJAK1JAK2CCNE1CDK2 | |
| SCHEMBL5766281 | 0.76 | PARP1 (0.36) | ALDH1A1MAPT | |
| SCHEMBL5768949 | 0.73 | L3MBTL3 (0.50) | SMN1; SMN2 | |
| SCHEMBL5767184 | 0.73 | OPRL1 (0.49) | TP53 | |
| SCHEMBL5769747 | 0.68 | ALDH1A1 (0.52) | LMNAJAK3ALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL28830816 | 0.60 | LMNA (0.41) | LMNAALDH1A1 | |
| SCHEMBL28257968 | 0.60 | IDO1 (0.43) | LMNAJAK1JAK2 | |
| SCHEMBL19331297 | 0.59 | POLB (0.39) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL23863015 | 0.59 | IRAK4 (0.41) | LMNAJAK1JAK2CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1625130-A2 | HIV INTEGRASE INHIBITORS | Tibotec Pharmaceuticals Ltd. (IE) | 2006-02-15 | — | — | EP | disclosed |
| WO-2004096807-A2 | HIV INTEGRASE INHIBITORS | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2004-11-11 | — | — | WO | disclosed |