Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PROKR1 | Q8TCW9 | 18/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4686593 | 0.91 | CHRNB2 (0.46) | PROKR1ESR1ESR2CHRNB2CHRNA4 | |
| SCHEMBL5769208 | 0.84 | CHRNB2 (0.41) | PROKR1ESR1ESR2CHRNB2CHRNA4 | |
| Hydrochloric Acid SCHEMBL7092182 | 0.83 | CHRNB2 (0.59) | PROKR1CHRNB2CHRNA4 | |
| SCHEMBL2060704 | 0.83 | ESR1 (0.40) | PROKR1ESR1ESR2CHRNB2CHRNA4 | |
| SCHEMBL5769218 | 0.83 | ESR1 (0.40) | PROKR1ESR1ESR2 | |
| SCHEMBL6396338 | 0.83 | ESR1 (0.40) | PROKR1ESR1ESR2 | |
| SCHEMBL5770265 | 0.82 | RBP4 (0.47) | PROKR1ESR1ESR2 | |
| SCHEMBL2274727 | 0.81 | PROKR1 (0.43) | PROKR1 | |
| SCHEMBL5767104 | 0.81 | CHRNA1 (0.49) | PROKR1ESR1ESR2CHRNB2CHRNA4 | |
| SCHEMBL2277918 | 0.79 | HSD11B1 (0.46) | PROKR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050020616-A1 | Aryl fused azapolycyclic compounds | PFIZER INC | 2005-01-27 | — | — | US | claimed |
| EP-1648872-A2 | ARYL FUSED AZAPOLYCYCLIC COMPOUNDS | Pfizer Products Inc. (US) | 2006-04-26 | — | — | EP | disclosed |
| WO-2005007630-A2 | ARYL FUSED AZAPOLYCYCLIC COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2005-01-27 | — | — | WO | disclosed |
| US-20050020616-A1 | Aryl fused azapolycyclic compounds | PFIZER INC | 2005-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050020616-A1 | Aryl fused azapolycyclic compounds | GRIN2C, GRIN2A, GRIN2B | PROKR1 2234/4885ESR1 1594/4885ESR2 1154/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.