Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 8/20 | 0.48 |
| ▸ | MEN1 | O00255 | 7/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | HTT | P42858 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | NR1D1 | P20393 | 6/20 | 0.44 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10130583 | 0.86 | KMT2A (0.50) | KMT2AMEN1MAPTHTTKDM4E | |
| SCHEMBL8421694 | 0.76 | MAPT (0.48) | KMT2AMEN1MAPTHTTKDM4E | |
| SCHEMBL5047015 | 0.76 | MAPT (0.46) | KMT2AMEN1MAPTHTTKDM4E | |
| SCHEMBL8421691 | 0.76 | MAPT (0.48) | KMT2AMEN1MAPTHTTKDM4E | |
| SCHEMBL25486356 | 0.76 | NR1D1 (0.53) | KMT2AMEN1MAPTHTTKDM4E | |
| SCHEMBL10160727 | 0.76 | KMT2A (0.54) | KMT2AMEN1MAPTHTTKDM4E | |
| SCHEMBL960965 | 0.76 | MAPT (0.53) | KMT2AMEN1MAPTHTTKDM4E | |
| SCHEMBL959890 | 0.75 | MAPT (0.44) | KMT2AMEN1MAPTHTTKDM4E | |
| SCHEMBL18720620 | 0.75 | MAPT (0.47) | KMT2AMEN1MAPTHTTKDM4E | |
| SCHEMBL8528925 | 0.74 | NR1D1 (0.48) | KMT2AMEN1MAPTHTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1613612-A2 | BIOREDUCTIVELY-ACTIVATED PRODRUGS | Angiogene Pharmaceuticals Limited (GB) | 2006-01-11 | — | — | EP | disclosed |
| WO-2004085421-A2 | BIOREDUCTIVELY-ACTIVATED PRODRUGS | ANGIOGENE PHARMACEUTICALS LIMITED (GB) | 2004-10-07 | — | — | WO | disclosed |