Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | HTT | P42858 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.50 |
| ▸ | MEN1 | O00255 | 7/20 | 0.50 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | NR1D1 | P20393 | 6/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8423313 | 0.96 | MAPT (0.50) | MAPTKDM4EHTTALDH1A1L3MBTL1 | |
| Phenol SCHEMBL27464528 | 0.88 | NR1D1 (0.47) | MAPTKDM4EHTTALDH1A1L3MBTL1 | |
| SCHEMBL5182378 | 0.84 | KMT2A (0.51) | MAPTKDM4EHTTALDH1A1L3MBTL1 | |
| SCHEMBL7048967 | 0.79 | KMT2A (0.54) | MAPTKDM4EHTTALDH1A1L3MBTL1 | |
| SCHEMBL10160727 | 0.79 | KMT2A (0.54) | MAPTKDM4EHTTALDH1A1L3MBTL1 | |
| SCHEMBL4880954 | 0.79 | MAPT (0.53) | MAPTKDM4EHTTALDH1A1L3MBTL1 | |
| SCHEMBL7753003 | 0.79 | MAPT (0.53) | MAPTKDM4EHTTALDH1A1L3MBTL1 | |
| SCHEMBL27834139 | 0.79 | MAPT (0.49) | MAPTKDM4EHTTALDH1A1L3MBTL1 | |
| SCHEMBL9449945 | 0.77 | MEN1 (0.49) | MAPTKDM4EHTTALDH1A1L3MBTL1 | |
| SCHEMBL6261093 | 0.77 | MAPT (0.52) | MAPTKDM4EHTTALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 83 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230365559-A1 | NOVEL AMINOPYRIDINES AND THEIR USE IN TREATING CANCER | AUCKLAND UNISERVICES LIMITED (NZ) | 2023-11-16 | — | — | US | disclosed |
| EP-4217357-A1 | NOVEL AMINOPYRIDINES AND THEIR USE IN TREATING CANCER | Auckland Uniservices Limited (NZ) | 2023-08-02 | — | — | EP | disclosed |
| US-20230167142-A1 | METHODS FOR THE MONO-AMIDATION OF PHOSPHATES AND PHOSPHONATES | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2023-06-01 | — | — | US | disclosed |
| US-20230063457-A1 | DNA-PK INHIBITING COMPOUNDS | PROVINCIAL HEALTH SERVICES AUTHORITY (CA) | 2023-03-02 | — | — | US | disclosed |
| WO-2022064430-A1 | NOVEL AMINOPYRIDINES AND THEIR USE IN TREATING CANCER | AUCKLAND UNISERVICES LIMITED (NZ) | 2022-03-31 | — | — | WO | disclosed |
| US-20220089620-A1 | INHIBITORS OF THE ENZYME ENOLASE FOR PRECISION ONCOLOGY | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2022-03-24 | — | — | US | disclosed |
| CN-110437281-B | Pyridinium-modified prodrug micromolecules containing different nitro aromatic heterocycles | 南开大学 | 2022-03-15 | — | — | CN | disclosed |
| WO-2021202886-A1 | METHODS FOR THE MONO-AMIDATION OF PHOSPHATES AND PHOSPHONATES | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2021-10-07 | — | — | WO | disclosed |
| WO-2020154742-A1 | INHIBITORS OF THE ENZYME ENOLASE FOR PRECISION ONCOLOGY | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2020-07-30 | — | — | WO | disclosed |
| CN-111440141-A | Preparation method of hydroxymethyl substituted aromatic heterocyclic compound | 安徽泽升科技有限公司 | 2020-07-24 | — | — | CN | disclosed |
| US-5716944-A | USEFUL AS PROPHYLACTIC AND THERAPEUTIC AGENTS OF VARIOUS METABOLIC BONE DISEASES SUCH AS OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-02-10 | — | — | US | disclosed |
| CN-1151744-A | Phosphonic acid compounds, their prodn. and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1997-06-11 | — | — | CN | disclosed |
| EP-0769015-A1 | PHOSPHONIC ACID COMPOUNDS, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1997-04-23 | — | — | EP | disclosed |
| EP-0705257-A1 | AMINOACID DERIVATIVES AS NO SYNTHASE INHIBITORS | THE WELLCOME FOUNDATION LIMITED (GB) | 1996-04-10 | — | — | EP | disclosed |
| EP-0697022-A1 | PHOSPHORAMIDATES USEFUL AS ANTITUMOR AGENTS | Research Corporation Technologies, Inc (US) | 1996-02-21 | — | — | EP | disclosed |
| WO-1996001267-A1 | PHOSPHONIC ACID COMPOUNDS, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-01-18 | — | — | WO | disclosed |
| US-5472956-A | Treating lung, breast, colon, ovaries or melanomas | RESEARCH CORPORATION TECHNOLOGIES, INC. (US) | 1995-12-05 | — | — | US | disclosed |
| WO-1995000505-A1 | AMINOACID DERIVATIVES AS NO SYNTHASE INHIBITORS | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-01-05 | — | — | WO | disclosed |
| WO-1994025471-A1 | PHOSPHORAMIDATES USEFUL AS ANTITUMOR AGENTS | RESEARCH CORPORATION TECHNOLOGIES, INC. (US) | 1994-11-10 | — | — | WO | disclosed |
| US-5306727-A | Selectively cytotoxic in hypoxic cells | RESEARCH CORPORATION TECHNOLOGIES, INC. (US) | 1994-04-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220089620-A1 | INHIBITORS OF THE ENZYME ENOLASE FOR PRECISION ONCOLOGY | ENO1, SERPINB1, ENPEP | MAPT 1234/4885KDM4E 1752/4885HTT 3487/4885 |
| US-20230063457-A1 | DNA-PK INHIBITING COMPOUNDS | DCK, POLK, ERCC2 | MAPT 3302/4885KDM4E 760/4885HTT 3752/4885 |
| US-20230167142-A1 | METHODS FOR THE MONO-AMIDATION OF PHOSPHATES AND PHOSPHONATES | PHPT1, PPIP5K2, PNP | MAPT 3158/4885KDM4E 3560/4885HTT 2659/4885 |
| US-20230365559-A1 | NOVEL AMINOPYRIDINES AND THEIR USE IN TREATING CANCER | DCK, DTYMK, TYMP | MAPT 4128/4885KDM4E 770/4885HTT 4800/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.