Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.46 |
| ▸ | HTT | P42858 | 7/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 7/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | POLB | P06746 | 5/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | MEN1 | O00255 | 6/20 | 0.44 |
| ▸ | NR1D1 | P20393 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | CASP3 | P42574 | 2/20 | 0.38 |
| ▸ | CASP9 | P55211 | 2/20 | 0.38 |
| ▸ | CASP6 | P55212 | 2/20 | 0.38 |
| ▸ | CASP8 | Q14790 | 2/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL959890 | 0.88 | MAPT (0.44) | MAPTHTTL3MBTL1KDM4EPOLB | |
| SCHEMBL5769414 | 0.76 | KMT2A (0.48) | MAPTHTTL3MBTL1KDM4EPOLB | |
| SCHEMBL5042133 | 0.74 | SMN1; SMN2 (0.47) | MAPTL3MBTL1POLBKMT2AALDH1A1 | |
| SCHEMBL6311420 | 0.73 | MEN1 (0.47) | MAPTHTTPOLBGAAKMT2A | |
| SCHEMBL8421694 | 0.73 | MAPT (0.48) | MAPTHTTL3MBTL1KDM4EPOLB | |
| SCHEMBL8421691 | 0.73 | MAPT (0.48) | MAPTHTTL3MBTL1KDM4EPOLB | |
| SCHEMBL26613727 | 0.73 | ALDH1A1 (0.46) | MAPTPOLBGAAKMT2AALDH1A1 | |
| SCHEMBL10130583 | 0.73 | KMT2A (0.50) | MAPTHTTL3MBTL1KDM4EPOLB | |
| SCHEMBL3070837 | 0.71 | MAPT (0.44) | MAPTHTTL3MBTL1KDM4EPOLB | |
| SCHEMBL8528925 | 0.71 | NR1D1 (0.48) | MAPTHTTL3MBTL1KDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1982982-A1 | NOVEL COUMARIN DERIVATIVE HAVING ANTITUMOR ACTIVITY | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2008-10-22 | — | — | EP | disclosed |