Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SLC13A5 | Q86YT5 | 9/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28207743 | 0.84 | ALDH1A1 (0.47) | ALDH1A1KDM4ELMNAMAPTALOX15 | |
| SCHEMBL3443147 | 0.80 | ALDH1A1 (0.50) | ALDH1A1KDM4ELMNAMAPTALOX15 | |
| SCHEMBL28991911 | 0.79 | ALDH1A1 (0.48) | ALDH1A1KDM4ELMNAMAPTALOX15 | |
| Citric Acid SCHEMBL5769500 | 0.78 | ALDH1A1 (0.62) | ALDH1A1KDM4ELMNAMAPTALOX15 | |
| SCHEMBL985035 | 0.77 | GAA (0.43) | ALDH1A1KDM4ELMNAMAPTALOX15 | |
| SCHEMBL22745718 | 0.74 | CYP2C19 (0.46) | ALDH1A1KDM4ELMNAMAPT | |
| Citric Acid SCHEMBL7744389 | 0.73 | ALDH1A1 (0.75) | ALDH1A1KDM4ELMNAMAPTALOX15 | |
| Citric Acid SCHEMBL28030414 | 0.73 | ALDH1A1 (0.83) | ALDH1A1KDM4ELMNAMAPTALOX15 | |
| Citric Acid SCHEMBL8586388 | 0.73 | ALDH1A1 (0.94) | ALDH1A1KDM4ELMNAMAPTALOX15 | |
| Citric Acid SCHEMBL227914 | 0.73 | ALDH1A1 (0.94) | ALDH1A1KDM4ELMNAMAPTALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732893-A2 | ALPHA ARYL OR HETEROARYL METHYL BETA PIPERIDINO PROPANAMIDE COMPOUNDS AS ORL1-RECEPTOR ANTAGONIST | Pfizer Japan, Inc. (JP) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005092858-A2 | ALPHA ARYL OR HETEROARYL METHYL BETA PIPERIDINO PROPANAMIDE COMPOUNDS AS ORL1-RECEPTOR ANTAGONIST | PFIZER JAPAN INC. (JP) | 2005-10-06 | — | — | WO | disclosed |