Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.75 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | SLC13A5 | Q86YT5 | 8/20 | 0.42 |
| ▸ | HMGCR | P04035 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | ACLY | P53396 | 3/20 | 0.38 |
| ▸ | CPT2 | P23786 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL94288 | 0.98 | ALDH1A1 (0.71) | ALDH1A1TSHRKDM4ELMNAMAPT | |
| Citric Acid SCHEMBL125278 | 0.98 | ALDH1A1 (0.71) | ALDH1A1TSHRKDM4ELMNAMAPT | |
| Citric Acid SCHEMBL5875237 | 0.98 | ALDH1A1 (0.71) | ALDH1A1TSHRKDM4ELMNAMAPT | |
| Citric Acid SCHEMBL28147135 | 0.98 | ALDH1A1 (0.71) | ALDH1A1TSHRKDM4ELMNAMAPT | |
| Citric Acid SCHEMBL28826306 | 0.95 | ALDH1A1 (0.68) | ALDH1A1TSHRKDM4ELMNAMAPT | |
| Citric Acid SCHEMBL28246171 | 0.93 | ALDH1A1 (0.65) | ALDH1A1TSHRKDM4ELMNAMAPT | |
| Citric Acid SCHEMBL5874250 | 0.91 | ALDH1A1 (0.62) | ALDH1A1TSHRKDM4ELMNAMAPT | |
| Citric Acid SCHEMBL5874239 | 0.91 | ALDH1A1 (0.62) | ALDH1A1TSHRKDM4ELMNAMAPT | |
| Citric Acid SCHEMBL23944 | 0.89 | ALDH1A1 (0.94) | ALDH1A1TSHRKDM4ELMNAMAPT | |
| Citric Acid SCHEMBL30338259 | 0.89 | ALDH1A1 (0.94) | ALDH1A1TSHRKDM4ELMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4326245-A1 | ANTIMICROBIAL COMPOSITIONS | University of South Florida (US) | 2024-02-28 | — | — | EP | disclosed |
| US-20240043618-A1 | ANTIMICROBIAL COMPOSITIONS | UNIVERSITY OF SOUTH FLORIDA | 2024-02-08 | — | — | US | disclosed |
| CN-105026503-A | Overcoat compositions, coated substrates, and related methods | AVERY DENNISON CORP | 2015-11-04 | — | — | CN | disclosed |
| US-20020016005-A1 | Methods for detecting an acid or base in an environment, measuring the concentration of an acid or base in an environment, or measuring the PH of an environment and sensors thereof | PHOTONIC SENSOR SYSTEMS | 2002-02-07 | — | — | US | disclosed |
| EP-1127263-A1 | METHODS AND SENSORS FOR DETECTING OR MEASURING AN ACID OR BASE | Photonic Sensor Systems (US) | 2001-08-29 | — | — | EP | disclosed |
| WO-2000026642-A9 | METHODS AND SENSORS FOR DETECTING OR MEASURING AN ACID OR BASE | PHOTONIC SENSOR SYSTEMS (US) | 2000-09-21 | — | — | WO | disclosed |
| WO-2000026642-A1 | METHODS AND SENSORS FOR DETECTING OR MEASURING AN ACID OR BASE | PHOTONIC SENSOR SYSTEMS (US) | 2000-05-11 | — | — | WO | disclosed |
| WO-1998042355-A1 | PHOSPHATE-BINDING POLYMERS COMBINED WITH A CALCIUM SUPPLEMENT FOR ORAL ADMINISTRATION | GELTEX PHARMACEUTICALS, INC. (US) | 1998-10-01 | — | — | WO | disclosed |