Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 2/20 | 0.72 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | FPR1 | P21462 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3572398 | 0.90 | CYP11B2 (0.79) | CYP11B1CYP11B2CYP3A4ALDH1A1KDM4E | |
| SCHEMBL3574211 | 0.89 | CYP11B1 (0.66) | CYP11B1CYP11B2CYP3A4ALDH1A1HDAC6 | |
| Hydrochloric Acid SCHEMBL3572437 | 0.89 | CYP11B2 (0.78) | CYP11B1CYP11B2CYP3A4ALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL3574374 | 0.88 | CYP11B1 (0.65) | CYP11B1CYP11B2CYP3A4ALDH1A1HDAC6 | |
| SCHEMBL3569027 | 0.87 | CYP11B1 (0.75) | CYP11B1CYP11B2CYP3A4 | |
| SCHEMBL8360541 | 0.87 | CYP11B2 (0.75) | CYP11B1CYP11B2CYP3A4ALDH1A1 | |
| SCHEMBL5774663 | 0.86 | CYP11B2 (0.62) | CYP11B1CYP11B2CYP3A4HDAC6HDAC1 | |
| Hydrochloric Acid SCHEMBL5229773 | 0.86 | CYP11B1 (0.74) | CYP11B1CYP11B2CYP3A4 | |
| SCHEMBL3574602 | 0.84 | CYP11B2 (1.00) | CYP11B1CYP11B2 | |
| SCHEMBL3571246 | 0.81 | CYP11B2 (0.67) | CYP11B1CYP11B2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537114-B1 | ORGANIC COMPOUNDS AS AGENTS FOR THE TREATMENT OF ALDOSTERONE MEDIATED CONDITIONS | NOVARTIS AG (CH) | 2006-08-09 | — | — | EP | claimed |