Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 3/20 | 0.62 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5769986 | 0.86 | CYP11B1 (0.72) | CYP11B2CYP11B1CYP3A4HDAC6HDAC1 | |
| SCHEMBL3572398 | 0.82 | CYP11B2 (0.79) | CYP11B2CYP11B1CYP3A4TP53 | |
| SCHEMBL3574211 | 0.82 | CYP11B1 (0.66) | CYP11B2CYP11B1CYP3A4HDAC6TP53 | |
| Hydrochloric Acid SCHEMBL3572437 | 0.81 | CYP11B2 (0.78) | CYP11B2CYP11B1CYP3A4TP53 | |
| Hydrochloric Acid SCHEMBL3574374 | 0.81 | CYP11B1 (0.65) | CYP11B2CYP11B1CYP3A4HDAC6TP53 | |
| SCHEMBL3578304 | 0.80 | CYP11B2 (0.66) | CYP11B2CYP11B1CYP3A4MAPTCYP19A1 | |
| SCHEMBL3569027 | 0.79 | CYP11B1 (0.75) | CYP11B2CYP11B1CYP3A4CYP19A1KMT2A | |
| SCHEMBL8360541 | 0.79 | CYP11B2 (0.75) | CYP11B2CYP11B1CYP3A4KMT2A | |
| SCHEMBL3577749 | 0.79 | CYP11B1 (0.65) | CYP11B2CYP11B1CYP3A4TP53MAPT | |
| Hydrochloric Acid SCHEMBL5229773 | 0.79 | CYP11B1 (0.74) | CYP11B2CYP11B1CYP3A4CYP19A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537114-B1 | ORGANIC COMPOUNDS AS AGENTS FOR THE TREATMENT OF ALDOSTERONE MEDIATED CONDITIONS | NOVARTIS AG (CH) | 2006-08-09 | — | — | EP | claimed |