Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 12/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 12/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 12/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 12/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 11/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.32 |
| ▸ | RAB9A | P51151 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5770463 | 0.85 | ALDH1A1 (0.36) | KMT2ANPC1RAB9AKDM4EMEN1 | |
| SCHEMBL5768555 | 0.82 | GABRA1 (0.33) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL6217514 | 0.82 | GABRA1 (0.33) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL6218809 | 0.81 | HMGCR (0.32) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL5771081 | 0.81 | KDM4E (0.34) | GABRA1GABRG2GABRB3KMT2ANPC1 | |
| SCHEMBL5770695 | 0.78 | JAK2 (0.36) | — | |
| SCHEMBL5261097 | 0.78 | GABRA1 (0.44) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL6217363 | 0.77 | PLCG1 (0.38) | KMT2ANPC1RAB9AKDM4EMEN1 | |
| SCHEMBL31729433 | 0.73 | GABRA1 (0.44) | GABRA1GABRG2GABRB3GABRA3GABRA5 | |
| SCHEMBL6102107 | 0.71 | ALDH1A1 (0.39) | KMT2ANPC1RAB9AKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1294133-C | Imidazo-pyrimidine derivatives as ligands for GABA receptors | MERCK SHARP & DOHME (GB) | 2007-01-10 | — | — | CN | disclosed |
| EP-1383768-B1 | IMIDAZO-PYRIMIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME (GB) | 2006-09-06 | — | — | EP | disclosed |
| EP-1381606-B1 | IMIDAZO-PYRIMIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME (GB) | 2005-07-20 | — | — | EP | disclosed |
| CN-1498218-A | Imidazo-pyrimidine derivatives as GABA receptor ligands | Ĭ�ˡ�����-��ķ��˾ | 2004-05-19 | — | — | CN | disclosed |