Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3114797 | 0.70 | PIK3CD (0.51) | MAPTLMNAKMT2AMEN1ALDH1A1 | |
| SCHEMBL659899 | 0.67 | CA12 (0.49) | MAPTLMNAKMT2AMEN1ALDH1A1 | |
| SCHEMBL3113306 | 0.67 | HTT (0.47) | MAPTLMNAKMT2AMEN1ALDH1A1 | |
| SCHEMBL9213082 | 0.65 | IDO1 (0.39) | MAPTLMNAKMT2AMEN1ALDH1A1 | |
| SCHEMBL17616743 | 0.64 | MAPT (0.47) | MAPTLMNAKMT2AMEN1ALDH1A1 | |
| SCHEMBL3868087 | 0.64 | ALDH1A1 (0.56) | MAPTLMNAKMT2AMEN1ALDH1A1 | |
| SCHEMBL22409591 | 0.63 | ALDH1A1 (0.60) | MAPTLMNAKMT2AMEN1ALDH1A1 | |
| SCHEMBL18449325 | 0.63 | KMT2A (0.53) | MAPTLMNAKMT2AMEN1ALDH1A1 | |
| SCHEMBL28417525 | 0.63 | MAPT (0.51) | MAPTLMNAKMT2AMEN1ALDH1A1 | |
| SCHEMBL12562311 | 0.63 | TDO2 (0.57) | MAPTLMNAKMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1496910-A4 | KINASE INHIBITORS | ABBOTT LAB (US) | 2006-03-29 | — | — | EP | disclosed |
| EP-1496910-A1 | KINASE INHIBITORS | Abbott Laboratories (US) | 2005-01-19 | — | — | EP | disclosed |
| WO-2003080064-A1 | KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2003-10-02 | — | — | WO | disclosed |