Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 11/20 | 0.78 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.46 |
| ▸ | PRKCI | P41743 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5773817 | 0.99 | NPY5R (0.76) | NPY5RMCHR1PRKCISMN1; SMN2MEN1 | |
| SCHEMBL5772334 | 0.88 | NPY5R (0.78) | NPY5RPRKCISMN1; SMN2MEN1KMT2A | |
| SCHEMBL5773316 | 0.88 | NPY5R (1.00) | NPY5RPRKCISMN1; SMN2MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL5774363 | 0.86 | NPY5R (0.97) | NPY5RPRKCISMN1; SMN2MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL5773169 | 0.86 | NPY5R (0.74) | NPY5RPRKCISMN1; SMN2MEN1KMT2A | |
| SCHEMBL5775005 | 0.77 | NPY5R (0.47) | NPY5RMCHR1PRKCISMN1; SMN2KDM4E | |
| SCHEMBL22727925 | 0.77 | NPY5R (0.65) | NPY5RPRKCIKDM4EALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL5774152 | 0.75 | NPY5R (0.46) | NPY5RMCHR1PRKCISMN1; SMN2KDM4E | |
| SCHEMBL5771137 | 0.73 | NPY5R (0.78) | NPY5RMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL5772544 | 0.73 | NPY5R (0.82) | NPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054887-B1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | AMGEN INC (US) | 2006-04-12 | — | — | EP | claimed |
| EP-1054887-B1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | AMGEN INC (US) | 2006-04-12 | — | — | EP | disclosed |
| US-6583154-B1 | Neuropeptide Y antagonist; pyrrolo-(3,2-b)pyridines and pyrrolo-(3,2-d)pyrimidines | AMGEN INC. | 2003-06-24 | — | — | US | disclosed |
| US-6187777-B1 | PYRROLO(3,2-D)PYRIMIDINE DERIVATIVES; NEUROPEPTIDE Y AND CORTICOTROPIN RELEASING FACTOR MODULATORS; DIETETICS; ANTIDIABETIC, ANTIINFLAMMATORY, AND ANTITUMOR AGENTS | AMGEN INC. | 2001-02-13 | — | — | US | disclosed |