Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 2/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | STK17B | O94768 | 1/20 | 0.35 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.35 |
| ▸ | PDE8B | O95263 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5801498 | 0.89 | TRPV1 (0.41) | ALOX5APFEN1TRPV1ALDH1A1ATM | |
| SCHEMBL8262110 | 0.88 | TRPV1 (0.40) | ALOX5APFEN1TRPV1ALDH1A1ATM | |
| SCHEMBL5802463 | 0.87 | GRM5 (0.37) | ALOX5APFEN1TRPV1ALDH1A1ATM | |
| SCHEMBL5800853 | 0.82 | ALDH1A1 (0.39) | ALOX5APFEN1TRPV1ALDH1A1CHEK2 | |
| SCHEMBL8515983 | 0.81 | CHEK2 (0.40) | TRPV1ALDH1A1ATMCHEK2IRAK4 | |
| SCHEMBL5483612 | 0.79 | ATM (0.39) | ALOX5APFEN1TRPV1ALDH1A1ATM | |
| SCHEMBL5484745 | 0.76 | ATM (0.39) | ALOX5APFEN1TRPV1ATMCHEK2 | |
| SCHEMBL5810771 | 0.74 | PDE8B (0.35) | ALOX5APFEN1TRPV1ATMCHEK2 | |
| SCHEMBL5475212 | 0.73 | ATM (0.37) | ALOX5APFEN1TRPV1ALDH1A1ATM | |
| SCHEMBL5483406 | 0.73 | ALOX5AP (0.39) | ALOX5APFEN1TRPV1ALDH1A1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006066899-A1 | NOVEL THROMBIN INHIBITORS | SANTHERA PHARMACEUTICALS (SCHWEIZ) AG (CH) | 2006-06-29 | — | — | WO | disclosed |
| EP-1674464-A1 | Novel thrombin inhibitors | Santhera Pharmaceuticals (Schweiz) GmbH (CH) | 2006-06-28 | — | — | EP | disclosed |
| EP-1655296-A1 | Thrombin inhibitors | Graffinity Pharmaceuticals AG (DE) | 2006-05-10 | — | — | EP | disclosed |
| WO-2006045459-A1 | THROMBIN INHIBITORS | SANTHERA PHARMACEUTICALS (SCHWEIZ) AG (CH) | 2006-05-04 | — | — | WO | disclosed |
| WO-2006045459-A1 | THROMBIN INHIBITORS | SANTHERA PHARMACEUTICALS (SCHWEIZ) AG (CH) | 2006-05-04 | — | — | WO | disclosed |