Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE8B | O95263 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.35 |
| ▸ | ATM | Q13315 | 2/20 | 0.35 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.34 |
| ▸ | AHCY | P23526 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
| ▸ | PLAT | P00750 | 1/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.33 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.33 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.32 |
| ▸ | FEN1 | P39748 | 1/20 | 0.32 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.32 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5802463 | 0.86 | GRM5 (0.37) | TRPV1ATMCHEK2AHCYF2 | |
| SCHEMBL5773134 | 0.76 | ATM (0.39) | PDE8BTRPV1ATMCHEK2MEN1 | |
| SCHEMBL5771502 | 0.74 | ALOX5AP (0.38) | PDE8BTRPV1ATMCHEK2PDE7B | |
| SCHEMBL5481717 | 0.74 | ATM (0.39) | PDE8BTRPV1ATMCHEK2F2 | |
| SCHEMBL5479621 | 0.72 | ATM (0.39) | PDE8BTRPV1ATMCHEK2F2 | |
| SCHEMBL24739379 | 0.71 | ATM (0.48) | PDE8BATMCHEK2MEN1KMT2A | |
| SCHEMBL29551182 | 0.71 | ATM (0.48) | PDE8BATMCHEK2MEN1KMT2A | |
| SCHEMBL5801498 | 0.71 | TRPV1 (0.41) | TRPV1ATMCHEK2PDE7BPRMT5 | |
| SCHEMBL5769599 | 0.70 | ATM (0.38) | PDE8BTRPV1ATMCHEK2MEN1 | |
| SCHEMBL8262110 | 0.70 | TRPV1 (0.40) | TRPV1ATMCHEK2PDE7BPRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1655296-A1 | Thrombin inhibitors | Graffinity Pharmaceuticals AG (DE) | 2006-05-10 | — | — | EP | disclosed |
| WO-2006045459-A1 | THROMBIN INHIBITORS | SANTHERA PHARMACEUTICALS (SCHWEIZ) AG (CH) | 2006-05-04 | — | — | WO | disclosed |
| WO-2006045459-A1 | THROMBIN INHIBITORS | SANTHERA PHARMACEUTICALS (SCHWEIZ) AG (CH) | 2006-05-04 | — | — | WO | disclosed |