Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | HRH2 | P25021 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 1/20 | 0.38 |
| ▸ | HTR1B | P28222 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8262110 | 0.92 | TRPV1 (0.40) | TRPV1APPHTR1AADRA2ADRD2 | |
| SCHEMBL5771502 | 0.89 | ALOX5AP (0.38) | TRPV1ALOX5APFEN1CHEK2ATM | |
| SCHEMBL5769284 | 0.83 | CHEK2 (0.40) | TRPV1APPHTR1AADRA2ADRD2 | |
| SCHEMBL5802463 | 0.83 | GRM5 (0.37) | TRPV1ALOX5APFEN1CHEK2ATM | |
| SCHEMBL5479174 | 0.81 | ATM (0.39) | TRPV1APPHTR1AADRA2ADRD2 | |
| SCHEMBL5800853 | 0.78 | ALDH1A1 (0.39) | TRPV1APPHTR1AADRA2ADRD2 | |
| SCHEMBL2915181 | 0.73 | ATM (0.46) | TRPV1APPHTR1AADRA2ADRD2 | |
| SCHEMBL3126719 | 0.73 | ATM (0.46) | TRPV1APPHTR1AADRA2ADRD2 | |
| SCHEMBL6174216 | 0.73 | ATM (0.46) | TRPV1APPHTR1AADRA2ADRD2 | |
| SCHEMBL8515983 | 0.72 | CHEK2 (0.40) | TRPV1CHEK2ATMALDH1A1PDE7B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1655296-A1 | Thrombin inhibitors | Graffinity Pharmaceuticals AG (DE) | 2006-05-10 | — | — | EP | disclosed |
| WO-2006045459-A1 | THROMBIN INHIBITORS | SANTHERA PHARMACEUTICALS (SCHWEIZ) AG (CH) | 2006-05-04 | — | — | WO | disclosed |