Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 11/20 | 0.70 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.70 |
| ▸ | PHLPP1 | O60346 | 2/20 | 0.70 |
| ▸ | ILK | Q13418 | 2/20 | 0.70 |
| ▸ | ALOX5 | P09917 | 5/20 | 0.61 |
| ▸ | PTGES | O14684 | 1/20 | 0.49 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14580950 | 0.89 | AKT1 (0.70) | AKT1PDPK1PHLPP1ILKALOX5 | |
| SCHEMBL18212526 | 0.89 | AKT1 (0.70) | AKT1PDPK1PHLPP1ILKALOX5 | |
| SCHEMBL15042781 | 0.88 | AKT1 (0.66) | AKT1PDPK1PHLPP1ILKALOX5 | |
| SCHEMBL23191967 | 0.88 | AKT1 (0.66) | AKT1PDPK1PHLPP1ILKALOX5 | |
| SCHEMBL6027769 | 0.88 | AKT1 (0.66) | AKT1PDPK1PHLPP1ILKALOX5 | |
| SCHEMBL5771699 | 0.87 | AKT1 (0.69) | AKT1PDPK1PHLPP1ILKALOX5 | |
| SCHEMBL8746281 | 0.85 | AKT1 (0.66) | AKT1PDPK1PHLPP1ILKALOX5 | |
| SCHEMBL5773613 | 0.85 | AKT1 (0.73) | AKT1PDPK1PHLPP1ILKALOX5 | |
| SCHEMBL8747826 | 0.85 | AKT1 (0.66) | AKT1PDPK1PHLPP1ILKALOX5 | |
| SCHEMBL4677441 | 0.84 | AKT1 (0.65) | AKT1PDPK1PHLPP1ILKALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160324823-A1 | TREATMENT OF MITOCHONDRIAL DISEASES | BIOELECTRON TECHNOLOGY CORPORATION | 2016-11-10 | — | — | US | disclosed |
| US-20130267538-A1 | TREATMENT OF MITOCHONDRIAL DISEASES | GALILEO PHARMACEUTICALS INC. | 2013-10-10 | — | — | US | disclosed |
| WO-2005032544-A1 | TREATMENT OF MITOCHONDRIAL DISEASES | GALILEO PHARMACEUTICALS, INC. (US) | 2005-04-14 | — | — | WO | disclosed |
| US-20050065099-A1 | Alzheimer's disease; Parkinson's disease; brain disorders; antiepileptic agents; amyotrophic lateral sclerosis; vision defects | EDISON PHARMACEUTICALS, INC. | 2005-03-24 | — | — | US | disclosed |
| JP-2002332231-A | γ-CEHC DELIVERY AGENT | TAKADA JIRO | 2002-11-22 | — | — | JP | disclosed |
| EP-0536036-B1 | Cardioprotective tocopherol analogs | MERRELL PHARMA INC (US) | 1998-02-25 | — | — | EP | disclosed |
| EP-0586518-B1 | CHOLESTEROL-LOWERING TOCOPHEROL ANALOGS | MERRELL PHARMA INC (US) | 1997-03-12 | — | — | EP | disclosed |
| EP-0550337-B1 | Tissue protective tocopherol analogs | MERRELL PHARMA INC (US) | 1997-02-12 | — | — | EP | disclosed |
| US-5500444-A | FREE RADICAL SCAVENGERS; CYTOPROTECTIVE, ANTIINFLAMMATORY, AND ANTIISCHEMIC AGENTS | HOECHST MARION ROUSSEL, INC. (US) | 1996-03-19 | — | — | US | disclosed |
| EP-0369874-B1 | Cardioprotective tocopherol analogs | MERRELL DOW PHARMA (US) | 1995-02-22 | — | — | EP | disclosed |
| EP-0550337-A1 | Tissue protective tocopherol analogs | MERRELL PHARMACEUTICALS INC. (US) | 1993-07-07 | — | — | EP | disclosed |
| EP-0550292-A1 | Tissue protective tocopherol analogs | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-07-07 | — | — | EP | disclosed |
| EP-0535283-A1 | Cardioprotective tocopherol analogs | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-04-07 | — | — | EP | disclosed |
| EP-0536036-A1 | Cardioprotective tocopherol analogs | MERRELL PHARMACEUTICALS INC. (US) | 1993-04-07 | — | — | EP | disclosed |
| US-5135945-A | Cholesterol-lowering tocopherol analogs | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-08-04 | — | — | US | disclosed |
| EP-0369874-A2 | Cardioprotective tocopherol analogs | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-05-23 | — | — | EP | disclosed |
| EP-0369083-A1 | Cardioprotective tocopherol analogs | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-05-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050065099-A1 | Alzheimer's disease; Parkinson's disease; brain disorders; antiepileptic agents; amyotrophic lateral sclerosis; vision defects | CLN6, LDHA, NLN | AKT1 3301/4885PDPK1 1893/4885PHLPP1 2723/4885 |
| US-20160324823-A1 | TREATMENT OF MITOCHONDRIAL DISEASES | NLN, FH, MFN2 | AKT1 3502/4885PDPK1 2127/4885PHLPP1 2278/4885 |
| US-20130267538-A1 | TREATMENT OF MITOCHONDRIAL DISEASES | NLN, FH, MFN2 | AKT1 3502/4885PDPK1 2127/4885PHLPP1 2278/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.