Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 8/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | MAST3 | O60307 | 1/20 | 0.34 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.33 |
| ▸ | ITK | Q08881 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.32 |
| ▸ | PDE2A | O00408 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5772303 | 1.00 | PDE4B (0.37) | PDE4BPDE7AMAPK8MAPK9MAPK10 | |
| SCHEMBL5768603 | 0.89 | FGFR2 (0.32) | PI4KBMAPK14CYP3A4 | |
| SCHEMBL5771480 | 0.82 | SSTR5 (0.47) | — | |
| SCHEMBL5774393 | 0.81 | MAPK14 (0.38) | PI4KBMAPK14CYP3A4 | |
| SCHEMBL6498820 | 0.81 | KDM4E (0.35) | PDE4BPDE7API4KBMAPK14 | |
| SCHEMBL5774648 | 0.80 | SYK (0.33) | PI4KBMAPK14CYP3A4 | |
| SCHEMBL5767550 | 0.80 | MAPK14 (0.38) | PI4KBMAPK14CYP3A4 | |
| SCHEMBL5769574 | 0.80 | PI4KB (0.36) | PI4KBMAPK14CYP3A4 | |
| SCHEMBL5773665 | 0.73 | PI4KB (0.54) | MAPK8MAPK9PI4KBMAPK14CYP3A4 | |
| SCHEMBL5774512 | 0.73 | ALDH1A1 (0.40) | PI4KBMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554272-B1 | BENZIMIDAZOLES AND BENZOTHIAZOLES AS INHIBITORS OF MAP KINASE | LILLY CO ELI (US) | 2006-10-25 | — | — | EP | disclosed |