Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 15/20 | 0.38 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.32 |
| ▸ | MET | P08581 | 1/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5774393 | 0.82 | MAPK14 (0.38) | MAPK14PI4KBCYP3A4 | |
| SCHEMBL5769574 | 0.81 | PI4KB (0.36) | MAPK14PI4KBCYP3A4 | |
| SCHEMBL5774512 | 0.80 | ALDH1A1 (0.40) | MAPK14PI4KBS1PR1 | |
| SCHEMBL5771593 | 0.80 | PDE4B (0.37) | MAPK14PI4KBCYP3A4 | |
| SCHEMBL5772303 | 0.80 | PDE4B (0.37) | MAPK14PI4KBCYP3A4 | |
| SCHEMBL5773723 | 0.80 | MAPK14 (0.41) | MAPK14CYP3A4 | |
| SCHEMBL5768603 | 0.79 | FGFR2 (0.32) | MAPK14PI4KBCNR2CYP3A4 | |
| SCHEMBL5768943 | 0.78 | ALDH1A1 (0.47) | MAPK14 | |
| SCHEMBL5770367 | 0.78 | MAPK14 (0.41) | MAPK14PI4KBCYP3A4 | |
| SCHEMBL5770827 | 0.78 | TP53 (0.48) | MAPK14PI4KBCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554272-B1 | BENZIMIDAZOLES AND BENZOTHIAZOLES AS INHIBITORS OF MAP KINASE | LILLY CO ELI (US) | 2006-10-25 | — | — | EP | disclosed |