SCHEMBL5772088

SCHEMBL5772088

Oc1nc(C(F)(F)F)[nH]c2cc(-c3ccccc3)nc1-2

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 1/20 0.48
ESR2 Q92731 1/20 0.48
KDM4E B2RXH2 4/20 0.44
HPGD P15428 4/20 0.44
ALDH1A1 P00352 3/20 0.44
CYP1A2 P05177 1/20 0.44
CYP2C9 P11712 1/20 0.44
CDC7 O00311 2/20 0.43
HSD17B10 Q99714 3/20 0.42
ADORA3 P0DMS8 1/20 0.39
ADORA2A P29274 1/20 0.39
ADORA1 P30542 1/20 0.39
TAAR1 Q96RJ0 2/20 0.38
TP53 P04637 2/20 0.38
THRB P10828 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
MEN1 O00255 2/20 0.37
KMT2A Q03164 2/20 0.37
NPSR1 Q6W5P4 1/20 0.37
NTSR1 P30989 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5772105 0.83 KDM4E (0.44) ESR1ESR2KDM4EHPGDALDH1A1
SCHEMBL5771494 0.80 CDC7 (0.48) KDM4EHPGDALDH1A1CYP1A2CYP2C9
SCHEMBL5774884 0.79 CDC7 (0.47) KDM4EHPGDALDH1A1CDC7HSD17B10
SCHEMBL5771811 0.78 CDC7 (0.46) KDM4EHPGDALDH1A1CYP1A2CYP2C9
SCHEMBL5774357 0.78 ADORA3 (0.48) KDM4EHPGDALDH1A1CYP1A2CDC7
SCHEMBL5777145 0.78 XDH (0.51) KDM4EHPGDALDH1A1CYP1A2CYP2C9
SCHEMBL5771921 0.74 SMN1; SMN2 (0.55) KDM4EHPGDALDH1A1CDC7HSD17B10
SCHEMBL5771204 0.74 ALDH1A1 (0.48) KDM4EHPGDALDH1A1CDC7HSD17B10
SCHEMBL5773858 0.74 ADORA1 (0.51) KDM4EHPGDALDH1A1CDC7HSD17B10
SCHEMBL5772305 0.73 ADORA3 (0.47) KDM4EHPGDALDH1A1CDC7HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1054887-B1 BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS AMGEN INC (US) 2006-04-12 EP disclosed
US-6583154-B1 Neuropeptide Y antagonist; pyrrolo-(3,2-b)pyridines and pyrrolo-(3,2-d)pyrimidines AMGEN INC. 2003-06-24 US disclosed
US-6187777-B1 PYRROLO(3,2-D)PYRIMIDINE DERIVATIVES; NEUROPEPTIDE Y AND CORTICOTROPIN RELEASING FACTOR MODULATORS; DIETETICS; ANTIDIABETIC, ANTIINFLAMMATORY, AND ANTITUMOR AGENTS AMGEN INC. 2001-02-13 US disclosed
EP-1054887-A1 BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS Amgen Inc. (US) 2000-11-29 EP disclosed
WO-1999040091-A1 BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS AMGEN INC. (US) 1999-08-12 WO disclosed