Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 10/20 | 0.38 |
| ▸ | CTSD | P07339 | 1/20 | 0.38 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.38 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.37 |
| ▸ | VIPR2 | P41587 | 1/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.36 |
| ▸ | ITGAV | P06756 | 1/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6763344 | 0.92 | BACE1 (0.39) | BACE1CTSD | |
| SCHEMBL7392821 | 0.81 | CTSD (0.49) | BACE1CTSD | |
| SCHEMBL1601744 | 0.80 | SPPL2A (0.42) | CTSDMAPT | |
| SCHEMBL1601742 | 0.80 | SPPL2A (0.42) | CTSDMAPT | |
| SCHEMBL6051065 | 0.77 | MAOB (0.42) | CTSD | |
| SCHEMBL4347480 | 0.77 | MAOA (0.44) | BACE1CTSDMAPT | |
| SCHEMBL6915284 | 0.74 | MAOB (0.40) | BACE1CTSDBACE2 | |
| SCHEMBL5771630 | 0.74 | MEP1B (0.39) | BACE1CTSDMAPTSMN1; SMN2 | |
| SCHEMBL4352403 | 0.74 | ABCB1 (0.39) | BACE1MAPTSMN1; SMN2 | |
| SCHEMBL8898130 | 0.73 | BACE1 (0.39) | BACE1CTSDBACE2ADRB3VIPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1637518-A2 | Inhibitors of aspartyl protease | Vertex Pharmaceuticals Incorporated (US) | 2006-03-22 | — | — | EP | disclosed |