Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 17/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 16/20 | 0.36 |
| ▸ | HTR2A | P28223 | 15/20 | 0.36 |
| ▸ | DRD2 | P14416 | 15/20 | 0.36 |
| ▸ | HTR1D | P28221 | 2/20 | 0.35 |
| ▸ | HTR1B | P28222 | 2/20 | 0.35 |
| ▸ | DRD3 | P35462 | 2/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5772179 | 0.88 | HTR1A (0.42) | HTR1AKCNH2HTR2ADRD2HTR1D | |
| SCHEMBL6407024 | 0.87 | HTR2A (0.42) | HTR1AHTR2ADRD2HTR7 | |
| SCHEMBL5738687 | 0.85 | HTR1A (0.41) | HTR1AKCNH2HTR2ADRD2HTR1D | |
| SCHEMBL5750335 | 0.79 | HTR1A (0.39) | HTR1AKCNH2HTR2ADRD2HTR1D | |
| SCHEMBL5738682 | 0.76 | SIGMAR1 (0.38) | HTR1AHTR2ADRD2HTR1DHTR1B | |
| SCHEMBL6407019 | 0.75 | HTR2A (0.46) | HTR1AKCNH2HTR2ADRD2HTR7 | |
| SCHEMBL5740933 | 0.74 | HTR2A (0.38) | HTR1AKCNH2HTR2ADRD2HTR1D | |
| SCHEMBL6400717 | 0.73 | HTR2A (0.48) | HTR1AKCNH2HTR2ADRD2HTR7 | |
| SCHEMBL6401393 | 0.72 | HTR2A (0.47) | HTR1AHTR2ADRD2HTR7 | |
| SCHEMBL6404382 | 0.71 | HTR2A (0.46) | HTR1AHTR2ADRD2HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1697334-A1 | HETEROCYCLIC SUBSTITUTED INDANE DERIVATIVES AND RELATED COMPOUNDS FOR THE TREATMENT OF SCHIZOPHRENIA | Warner-Lambert Company LLC (US) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005056540-A1 | HETEROCYCLIC SUBSTITUTED INDANE DERIVATIVES AND RELATED COMPOUNDS FOR THE TREATMENT OF SCHIZOPHRENIA | WARNER-LAMBERT COMPANY LLC (US) | 2005-06-23 | — | — | WO | disclosed |