Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.38 |
| ▸ | DRD2 | P14416 | 3/20 | 0.37 |
| ▸ | HTR7 | P34969 | 2/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | HTR1B | P28222 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | EBP | Q15125 | 2/20 | 0.34 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | EBPL | Q9BY08 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5750335 | 0.85 | HTR1A (0.39) | DRD2HTR7HTR2AHTR2CHTR2B | |
| SCHEMBL6400823 | 0.84 | DRD2 (0.48) | SIGMAR1DRD2HTR7HTR2AHTR1A | |
| SCHEMBL5739261 | 0.84 | HTR1A (0.40) | SIGMAR1DRD2HTR7HTR2AHTR2C | |
| SCHEMBL5740933 | 0.81 | HTR2A (0.38) | SIGMAR1DRD2HTR7HTR2AHTR2C | |
| SCHEMBL6405448 | 0.80 | HTR7 (0.51) | DRD2HTR7HTR2A | |
| SCHEMBL5738687 | 0.79 | HTR1A (0.41) | DRD2HTR7HTR2AHTR2CHTR2B | |
| SCHEMBL5739172 | 0.79 | ADRA1D (0.40) | HTR7HTR1AMEN1KMT2A | |
| SCHEMBL6399597 | 0.79 | HTR1A (0.56) | DRD2HTR7HTR2AHTR1A | |
| SCHEMBL5772179 | 0.79 | HTR1A (0.42) | DRD2HTR7HTR2AHTR2CHTR2B | |
| SCHEMBL6404206 | 0.78 | HTR2A (0.48) | SIGMAR1DRD2HTR7HTR2AHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1697334-A1 | HETEROCYCLIC SUBSTITUTED INDANE DERIVATIVES AND RELATED COMPOUNDS FOR THE TREATMENT OF SCHIZOPHRENIA | Warner-Lambert Company LLC (US) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005056540-A1 | HETEROCYCLIC SUBSTITUTED INDANE DERIVATIVES AND RELATED COMPOUNDS FOR THE TREATMENT OF SCHIZOPHRENIA | WARNER-LAMBERT COMPANY LLC (US) | 2005-06-23 | — | — | WO | disclosed |