Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 8/20 | 0.43 |
| ▸ | DRD2 | P14416 | 7/20 | 0.43 |
| ▸ | DRD3 | P35462 | 7/20 | 0.43 |
| ▸ | HTR2A | P28223 | 6/20 | 0.43 |
| ▸ | DRD1 | P21728 | 4/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.43 |
| ▸ | DRD5 | P21918 | 3/20 | 0.43 |
| ▸ | PARP1 | P09874 | 2/20 | 0.42 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 3/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5775621 | 0.89 | SIGMAR1 (0.48) | HTR1ADRD2DRD3HTR2ADRD1 | |
| SCHEMBL5773122 | 0.89 | MAPT (0.42) | HTR1ASIGMAR1TLR9DRD4HTR7 | |
| SCHEMBL5771894 | 0.89 | SIGMAR1 (0.49) | HTR1ADRD2DRD3HTR2ATMEM97 | |
| SCHEMBL5774541 | 0.84 | HTR1A (0.49) | HTR1ADRD2DRD3HTR2ADRD1 | |
| SCHEMBL7960754 | 0.84 | HTR1A (0.48) | HTR1ADRD2DRD3HTR2ADRD1 | |
| Hydrochloric Acid SCHEMBL5772589 | 0.84 | HTR1A (0.48) | HTR1ADRD2DRD3HTR2ADRD1 | |
| SCHEMBL5771879 | 0.83 | DRD2 (0.45) | HTR1ADRD2DRD3HTR2ADRD1 | |
| Hydrochloric Acid SCHEMBL5775839 | 0.83 | HTR1A (0.45) | HTR1ADRD2DRD3HTR2ADRD1 | |
| SCHEMBL5774579 | 0.81 | HTR1A (0.54) | HTR1ADRD2DRD3HTR2ADRD1 | |
| SCHEMBL5771928 | 0.81 | DRD2 (0.43) | HTR1ADRD2DRD3HTR2ADRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0885883-B1 | FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | MITSUBISHI PHARMA CORP (JP) | 2006-11-02 | — | — | EP | claimed |
| US-6187774-B1 | N-PIPERAZINYLALKYLINDAZOLE DERIVATIVES; PSYCHOLOGICAL DISORDERS, SCHIZOPHRENIA; SIDE EFFECT REDUCTION | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2001-02-13 | — | — | US | claimed |
| EP-0885883-A1 | FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1998-12-23 | — | — | EP | claimed |
| EP-0885883-B1 | FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | MITSUBISHI PHARMA CORP (JP) | 2006-11-02 | — | — | EP | disclosed |
| US-6187774-B1 | N-PIPERAZINYLALKYLINDAZOLE DERIVATIVES; PSYCHOLOGICAL DISORDERS, SCHIZOPHRENIA; SIDE EFFECT REDUCTION | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2001-02-13 | — | — | US | disclosed |
| EP-0885883-A1 | FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1998-12-23 | — | — | EP | disclosed |