Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 16/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 16/20 | 0.43 |
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7187618 | 0.73 | ALDH1A1 (0.44) | KDM4EMEN1ALDH1A1POLBMAPT | |
| SCHEMBL5774654 | 0.71 | NPY5R (0.41) | NSD3CCNT1CDK9KDM4EMEN1 | |
| SCHEMBL7190615 | 0.70 | KMT2A (0.48) | KDM4EALDH1A1KMT2A | |
| SCHEMBL5776182 | 0.68 | HPGDS (0.40) | CCNT1CDK9KDM4EMEN1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL5777280 | 0.67 | HPGDS (0.39) | CCNT1CDK9KDM4EMEN1ALDH1A1 | |
| SCHEMBL6981381 | 0.64 | HRH4 (0.62) | KDM4EMEN1ALDH1A1MAPTRAB9A | |
| SCHEMBL5775024 | 0.64 | NPY5R (0.53) | GABRA1GABRB2NSD3ALDH1A1KMT2A | |
| SCHEMBL5774225 | 0.64 | NPY5R (0.50) | KDM4EMEN1ALDH1A1POLBMAPT | |
| SCHEMBL10880344 | 0.63 | HTR2A (0.44) | GABRA1GABRB2CCNT1CDK9MEN1 | |
| SCHEMBL7553650 | 0.63 | PRCP (0.56) | GABRA1GABRB2NSD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6187777-B1 | PYRROLO(3,2-D)PYRIMIDINE DERIVATIVES; NEUROPEPTIDE Y AND CORTICOTROPIN RELEASING FACTOR MODULATORS; DIETETICS; ANTIDIABETIC, ANTIINFLAMMATORY, AND ANTITUMOR AGENTS | AMGEN INC. | 2001-02-13 | — | — | US | claimed |
| EP-1054887-B1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | AMGEN INC (US) | 2006-04-12 | — | — | EP | disclosed |
| US-6583154-B1 | Neuropeptide Y antagonist; pyrrolo-(3,2-b)pyridines and pyrrolo-(3,2-d)pyrimidines | AMGEN INC. | 2003-06-24 | — | — | US | disclosed |
| US-6187777-B1 | PYRROLO(3,2-D)PYRIMIDINE DERIVATIVES; NEUROPEPTIDE Y AND CORTICOTROPIN RELEASING FACTOR MODULATORS; DIETETICS; ANTIDIABETIC, ANTIINFLAMMATORY, AND ANTITUMOR AGENTS | AMGEN INC. | 2001-02-13 | — | — | US | disclosed |