Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7190615 | 0.76 | KMT2A (0.48) | ALDH1A1KDM4EKMT2AL3MBTL1HPGD | |
| SCHEMBL5772492 | 0.73 | GABRA1 (0.43) | ALDH1A1KDM4EMEN1KMT2AMAPT | |
| SCHEMBL5774543 | 0.67 | ADORA1 (0.48) | ALDH1A1KDM4EMEN1KMT2AMAPT | |
| SCHEMBL21077300 | 0.66 | KMT2A (0.57) | ALDH1A1KDM4EMEN1KMT2AMAPT | |
| SCHEMBL8756013 | 0.65 | KMT2A (0.59) | ALDH1A1KDM4EMEN1KMT2AMAPT | |
| SCHEMBL12590478 | 0.65 | MEN1 (0.59) | ALDH1A1KDM4EMEN1KMT2AMAPT | |
| SCHEMBL12620535 | 0.64 | ALDH1A1 (0.65) | ALDH1A1KDM4EMEN1KMT2AMAPT | |
| SCHEMBL10444909 | 0.63 | KDM4E (0.71) | ALDH1A1KDM4EMEN1KMT2AMAPT | |
| SCHEMBL5771482 | 0.63 | KDM4E (0.47) | ALDH1A1KDM4EMEN1KMT2AMAPT | |
| SCHEMBL5776767 | 0.63 | KDM4E (0.47) | ALDH1A1KDM4EMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6583154-B1 | Neuropeptide Y antagonist; pyrrolo-(3,2-b)pyridines and pyrrolo-(3,2-d)pyrimidines | AMGEN INC. | 2003-06-24 | — | — | US | disclosed |
| US-6187777-B1 | PYRROLO(3,2-D)PYRIMIDINE DERIVATIVES; NEUROPEPTIDE Y AND CORTICOTROPIN RELEASING FACTOR MODULATORS; DIETETICS; ANTIDIABETIC, ANTIINFLAMMATORY, AND ANTITUMOR AGENTS | AMGEN INC. | 2001-02-13 | — | — | US | disclosed |