Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | FLT1 | P17948 | 2/20 | 0.42 |
| ▸ | FLT4 | P35916 | 2/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | TNKS | O95271 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5771594 | 0.84 | TNKS (0.41) | RAB9ANPC1ALDH1A1MEN1KMT2A | |
| SCHEMBL4505454 | 0.81 | KCNA3 (0.44) | RAB9ANPC1ALDH1A1ALOX15HSD17B10 | |
| SCHEMBL1789380 | 0.76 | MEN1 (0.50) | RAB9ANPC1ALDH1A1ALOX15HSD17B10 | |
| SCHEMBL5157357 | 0.70 | — | — | |
| SCHEMBL3878829 | 0.69 | NPC1 (0.52) | RAB9ANPC1ALDH1A1HSD17B10MEN1 | |
| SCHEMBL4500091 | 0.69 | KDM4E (0.51) | ALDH1A1ALOX15HSD17B10MEN1KMT2A | |
| SCHEMBL8242900 | 0.68 | KDM4E (0.61) | RAB9ANPC1ALDH1A1ALOX15HSD17B10 | |
| SCHEMBL11085347 | 0.67 | PRKDC (0.45) | RAB9ANPC1ALDH1A1ALOX15HSD17B10 | |
| SCHEMBL29144867 | 0.66 | PLA2G2A (0.54) | RAB9ANPC1ALDH1A1ALOX15MEN1 | |
| SCHEMBL10372862 | 0.65 | ALOX15 (0.40) | RAB9ANPC1ALDH1A1ALOX15HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103864765-B | Benzazepine analog derivative containing five-membered ring, Preparation Method And The Use | TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH (CN) | 2016-02-10 | — | — | CN | disclosed |
| CN-103864765-A | Benzoazepine derivative containing five-membered heterocycle as well as preparation method and application of derivative | TIANJIN INST PHARM RESEARCH | 2014-06-18 | — | — | CN | disclosed |
| EP-1054887-B1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | AMGEN INC (US) | 2006-04-12 | — | — | EP | disclosed |
| US-6583154-B1 | Neuropeptide Y antagonist; pyrrolo-(3,2-b)pyridines and pyrrolo-(3,2-d)pyrimidines | AMGEN INC. | 2003-06-24 | — | — | US | disclosed |
| US-6187777-B1 | PYRROLO(3,2-D)PYRIMIDINE DERIVATIVES; NEUROPEPTIDE Y AND CORTICOTROPIN RELEASING FACTOR MODULATORS; DIETETICS; ANTIDIABETIC, ANTIINFLAMMATORY, AND ANTITUMOR AGENTS | AMGEN INC. | 2001-02-13 | — | — | US | disclosed |
| EP-1054887-A1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | Amgen Inc. (US) | 2000-11-29 | — | — | EP | disclosed |
| WO-1999040091-A1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | AMGEN INC. (US) | 1999-08-12 | — | — | WO | disclosed |