Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | AR | P10275 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | TNKS | O95271 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.42 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.42 |
| ▸ | GABRP | O00591 | 1/20 | 0.42 |
| ▸ | GABRD | O14764 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1344376 | 0.80 | PRKDC (0.56) | PRKDCMEN1KMT2AKDM4EAR | |
| SCHEMBL11084829 | 0.79 | EGFR (0.71) | PRKDCMEN1KMT2AKDM4ELMNA | |
| SCHEMBL11733368 | 0.75 | ALDH1A1 (0.49) | MEN1KMT2AKDM4ELMNASMN1; SMN2 | |
| SCHEMBL11085896 | 0.72 | NQO1 (0.54) | PRKDCMEN1KMT2AKDM4EAR | |
| SCHEMBL6964494 | 0.72 | PRKDC (0.49) | PRKDCMEN1KMT2AKDM4EAR | |
| SCHEMBL3427191 | 0.72 | PRKDC (0.49) | PRKDCMEN1KMT2AKDM4EAR | |
| SCHEMBL9179291 | 0.69 | PLA2G2A (0.49) | PRKDCMEN1KMT2AARSMN1; SMN2 | |
| SCHEMBL1176530 | 0.69 | ALDH1A1 (0.58) | PRKDCMEN1KMT2AKDM4EAR | |
| SCHEMBL9204834 | 0.69 | PRKDC (0.46) | PRKDCMEN1KMT2AKDM4ELMNA | |
| SCHEMBL14944131 | 0.68 | KDM4E (0.51) | MEN1KMT2AKDM4ELMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4471129-A | ANTIHISTAMINES | LILLY INDUSTRIES LIMITED (GB) | 1984-09-11 | — | — | US | disclosed |
| US-4448787-A | ANTIALLERGENS | LILLY INDUSTRIES LIMITED (GB) | 1984-05-15 | — | — | US | disclosed |
| US-4304728-A | 2,6-DIHYDROXY-2,5-HEXADIENOIC ACID DERIVATIVES, ANTIHISTAMINE INTERMEDIATES | LILLY INDUSTRIES LIMITED (GB) | 1981-12-08 | — | — | US | disclosed |