Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 4/20 | 0.30 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.30 |
| ▸ | YES1 | P07947 | 3/20 | 0.30 |
| ▸ | PIM1 | P11309 | 3/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.30 |
| ▸ | KDR | P35968 | 3/20 | 0.30 |
| ▸ | HIPK1 | Q86Z02 | 3/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5775173 | 0.98 | DHFR (0.30) | DHFR | |
| SCHEMBL5776561 | 0.83 | MEN1 (0.31) | — | |
| SCHEMBL5774485 | 0.82 | MEN1 (0.31) | — | |
| SCHEMBL5772664 | 0.82 | MEN1 (0.31) | — | |
| Hydrochloric Acid SCHEMBL5807142 | 0.81 | MEN1 (0.30) | — | |
| Hydrochloric Acid SCHEMBL5775252 | 0.81 | MEN1 (0.30) | — | |
| Hydrochloric Acid SCHEMBL5776956 | 0.81 | MEN1 (0.30) | — | |
| SCHEMBL5776818 | 0.81 | USP30 (0.35) | — | |
| SCHEMBL5771501 | 0.80 | LMNA (0.30) | — | |
| Hydrochloric Acid SCHEMBL5773710 | 0.79 | USP30 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054887-B1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | AMGEN INC (US) | 2006-04-12 | — | — | EP | claimed |
| US-6187777-B1 | PYRROLO(3,2-D)PYRIMIDINE DERIVATIVES; NEUROPEPTIDE Y AND CORTICOTROPIN RELEASING FACTOR MODULATORS; DIETETICS; ANTIDIABETIC, ANTIINFLAMMATORY, AND ANTITUMOR AGENTS | AMGEN INC. | 2001-02-13 | — | — | US | claimed |
| EP-1054887-B1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | AMGEN INC (US) | 2006-04-12 | — | — | EP | disclosed |
| US-6583154-B1 | Neuropeptide Y antagonist; pyrrolo-(3,2-b)pyridines and pyrrolo-(3,2-d)pyrimidines | AMGEN INC. | 2003-06-24 | — | — | US | disclosed |
| US-6187777-B1 | PYRROLO(3,2-D)PYRIMIDINE DERIVATIVES; NEUROPEPTIDE Y AND CORTICOTROPIN RELEASING FACTOR MODULATORS; DIETETICS; ANTIDIABETIC, ANTIINFLAMMATORY, AND ANTITUMOR AGENTS | AMGEN INC. | 2001-02-13 | — | — | US | disclosed |