Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 5/20 | 0.53 |
| ▸ | RXRB | P28702 | 5/20 | 0.53 |
| ▸ | NR4A2 | P43354 | 4/20 | 0.53 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.46 |
| ▸ | RXRG | P48443 | 2/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.40 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.40 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.40 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.40 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.40 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.40 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | CCNC | P24863 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5774926 | 0.84 | TP53 (0.44) | RXRARXRBNR4A2FFAR1RXRG | |
| SCHEMBL5770707 | 0.84 | RXRA (0.53) | RXRARXRBNR4A2FFAR1RXRG | |
| SCHEMBL5774472 | 0.81 | RXRA (0.50) | RXRARXRBNR4A2FFAR1RXRG | |
| SCHEMBL5774165 | 0.80 | ATM (0.39) | RXRARXRBNR4A2ATMPTPN2 | |
| SCHEMBL5774948 | 0.78 | FFAR1 (0.51) | RXRARXRBNR4A2FFAR1RXRG | |
| SCHEMBL5772923 | 0.77 | TSHR (0.55) | RXRARXRBFFAR1RXRGPOLB | |
| SCHEMBL5773868 | 0.77 | RXRA (0.53) | RXRARXRBNR4A2FFAR1RXRG | |
| SCHEMBL5773615 | 0.76 | RXRA (0.56) | RXRARXRBNR4A2FFAR1RXRG | |
| SCHEMBL5773925 | 0.75 | FFAR1 (0.44) | FFAR1PTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL3165982 | 0.75 | ALDH1A1 (0.47) | RXRARXRBNR4A2ATMPTPN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7022725-B2 | Isoxazole derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-04-04 | — | — | US | claimed |