Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | RXRA | P19793 | 4/20 | 0.50 |
| ▸ | RXRB | P28702 | 4/20 | 0.50 |
| ▸ | RXRG | P48443 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | FFAR4 | Q5NUL3 | 8/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.46 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5774948 | 0.87 | FFAR1 (0.51) | TSHRRXRARXRBRXRGKDM4E | |
| SCHEMBL5774472 | 0.86 | RXRA (0.50) | TSHRRXRARXRBRXRGKDM4E | |
| SCHEMBL5770527 | 0.85 | RXRA (0.53) | TSHRRXRARXRBRXRGFFAR4 | |
| SCHEMBL5772507 | 0.85 | RXRA (0.50) | RXRARXRBRXRGKDM4EALDH1A1 | |
| SCHEMBL5776861 | 0.85 | PPARA (0.48) | TSHRRXRARXRBRXRGKDM4E | |
| SCHEMBL5773998 | 0.85 | FFAR1 (0.46) | TSHRRXRARXRBRXRGKDM4E | |
| SCHEMBL5773868 | 0.85 | RXRA (0.53) | TSHRRXRARXRBRXRGFFAR1 | |
| SCHEMBL5774812 | 0.84 | FFAR1 (0.42) | TSHRRXRARXRBRXRGFFAR4 | |
| SCHEMBL5773378 | 0.83 | CYP11B1 (0.45) | TSHRKDM4EALDH1A1MAPTFFAR4 | |
| SCHEMBL5773615 | 0.83 | RXRA (0.56) | TSHRRXRARXRBRXRGFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7022725-B2 | Isoxazole derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-04-04 | — | — | US | claimed |
| US-20040048908-A1 | Isoxazole derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2004-03-11 | — | — | US | claimed |
| EP-1340749-A1 | ISOXAZOLE DERIVATIVES | Takeda Chemical Industries, Ltd. (JP) | 2003-09-03 | — | — | EP | claimed |
| US-20060084690-A1 | Isoxazole derivatives | MOMOSE YU | 2006-04-20 | — | — | US | disclosed |
| US-7022725-B2 | Isoxazole derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-04-04 | — | — | US | disclosed |
| US-20040048908-A1 | Isoxazole derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2004-03-11 | — | — | US | disclosed |
| EP-1340749-A1 | ISOXAZOLE DERIVATIVES | Takeda Chemical Industries, Ltd. (JP) | 2003-09-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060084690-A1 | Isoxazole derivatives | INSR, GPR119, INSRR | TSHR 534/4885RXRA 445/4885RXRB 494/4885 |
| US-20040048908-A1 | Isoxazole derivatives | GPR119, INSR, IRS1 | TSHR 583/4885RXRA 462/4885RXRB 550/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.