Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 4/20 | 0.62 |
| ▸ | DBF4 | Q9UBU7 | 4/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | DHODH | Q02127 | 7/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.53 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.53 |
| ▸ | RARA | P10276 | 1/20 | 0.49 |
| ▸ | RARB | P10826 | 1/20 | 0.49 |
| ▸ | RARG | P13631 | 1/20 | 0.49 |
| ▸ | HPGDS | O60760 | 1/20 | 0.48 |
| ▸ | ALPL | P05186 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5873072 | 0.84 | MAP2K4 (0.58) | CDC7DBF4ALDH1A1HSD17B10HPGD | |
| SCHEMBL4503056 | 0.82 | CDC7 (0.88) | CDC7DBF4ALDH1A1HSD17B10HPGD | |
| SCHEMBL8345636 | 0.78 | CDC7 (0.65) | CDC7DBF4ALDH1A1HSD17B10HPGD | |
| SCHEMBL4488472 | 0.78 | KDM4E (0.74) | ALDH1A1HPGDMEN1KMT2AKDM4E | |
| SCHEMBL5777277 | 0.77 | KDM4E (0.63) | ALDH1A1HSD17B10HPGDKDM4ERARA | |
| SCHEMBL953385 | 0.77 | CDC7 (1.00) | CDC7DBF4ALDH1A1HSD17B10TRPM8 | |
| SCHEMBL5873074 | 0.77 | KDM4E (0.58) | ALDH1A1HPGDMEN1CYP1A2CYP2C9 | |
| SCHEMBL16039074 | 0.76 | CDC7 (0.76) | CDC7DBF4ALDH1A1HSD17B10HPGD | |
| SCHEMBL5771654 | 0.76 | ALDH1A1 (0.65) | ALDH1A1HSD17B10HPGDCYP1A2CYP2C19 | |
| SCHEMBL8823153 | 0.76 | ALDH1A1 (0.75) | CDC7DBF4ALDH1A1HSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1664040-A1 | GYRASE INHIBITORS | PFIZER INC. (US) | 2006-06-07 | — | — | EP | disclosed |
| US-6984652-B2 | Gyrase inhibitors | WARNER-LAMBERT COMPANY LLC (US) | 2006-01-10 | — | — | US | disclosed |
| US-20050250823-A1 | Gyrase inhibitors | YAGER KRAIG | 2005-11-10 | — | — | US | disclosed |
| WO-2005026162-A1 | GYRASE INHIBITORS | PFIZER INC. (US) | 2005-03-24 | — | — | WO | disclosed |
| US-20050054697-A1 | Gyrase inhibitors | PFIZER INC. | 2005-03-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050054697-A1 | Gyrase inhibitors | TOP1, TOP2A, TOP2B | CDC7 120/4885DBF4 1446/4885ALDH1A1 2272/4885 |
| US-20050250823-A1 | Gyrase inhibitors | TOP1, TOP2A, TOP2B | CDC7 120/4885DBF4 1446/4885ALDH1A1 2272/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.