Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.32 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.32 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.32 |
| ▸ | NMT1 | P30419 | 2/20 | 0.31 |
| ▸ | SOS1 | Q07889 | 3/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 2/20 | 0.31 |
| ▸ | PRKCI | P41743 | 1/20 | 0.30 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7188454 | 0.99 | CHRM4 (0.37) | CHRM4KITPDPK1NPY5RMEN1 | |
| SCHEMBL5773747 | 0.76 | NPY5R (0.51) | CHRM4KITNPY5RMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL5774370 | 0.75 | NPY5R (0.50) | KITNPY5RMEN1KMT2ANPC1 | |
| SCHEMBL5771159 | 0.74 | RAB9A (0.42) | CHRM4KITNPY5RNPC1RAB9A | |
| SCHEMBL5772338 | 0.74 | KCNH2 (0.42) | KITPDPK1NPY5RRAB9AKCNH2 | |
| Hydrochloric Acid SCHEMBL5773821 | 0.73 | RAB9A (0.44) | CHRM4KITNPY5RNPC1RAB9A | |
| SCHEMBL19198488 | 0.73 | MEN1 (0.40) | CHRM4PDPK1NPY5RMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL5773172 | 0.72 | KCNH2 (0.41) | KITPDPK1NPY5RRAB9AKCNH2 | |
| SCHEMBL12105218 | 0.72 | PDPK1 (0.42) | PDPK1MEN1KMT2ANMT1PRKCI | |
| SCHEMBL5772009 | 0.65 | MEN1 (0.67) | NPY5RMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054887-B1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | AMGEN INC (US) | 2006-04-12 | — | — | EP | claimed |
| US-6583154-B1 | Neuropeptide Y antagonist; pyrrolo-(3,2-b)pyridines and pyrrolo-(3,2-d)pyrimidines | AMGEN INC. | 2003-06-24 | — | — | US | disclosed |