Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 2/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | PRKCI | P41743 | 1/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5773172 | 0.98 | KCNH2 (0.41) | KCNH2RAB9AKITMKNK1MKNK2 | |
| SCHEMBL5771159 | 0.88 | RAB9A (0.42) | KCNH2RAB9AKITNPY5RPRKCI | |
| SCHEMBL5773747 | 0.88 | NPY5R (0.51) | KCNH2RAB9AKITNPY5RPRKCI | |
| Hydrochloric Acid SCHEMBL5773821 | 0.87 | RAB9A (0.44) | KCNH2RAB9AKITNPY5RPRKCI | |
| Hydrochloric Acid SCHEMBL5774370 | 0.87 | NPY5R (0.50) | KCNH2RAB9AKITNPY5RPRKCI | |
| SCHEMBL5773890 | 0.74 | CHRM4 (0.38) | KCNH2RAB9AKITPDPK1NPY5R | |
| Hydrochloric Acid SCHEMBL7188454 | 0.73 | CHRM4 (0.37) | KCNH2RAB9AKITPDPK1NPY5R | |
| SCHEMBL5772334 | 0.69 | NPY5R (0.78) | KCNH2NPY5RPRKCI | |
| Hydrochloric Acid SCHEMBL5773169 | 0.67 | NPY5R (0.74) | KCNH2KITNPY5RPRKCI | |
| SCHEMBL5776584 | 0.66 | NPY5R (0.47) | RAB9ANPY5RPRKCICDC7DBF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054887-B1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | AMGEN INC (US) | 2006-04-12 | — | — | EP | claimed |