SCHEMBL5773896

SCHEMBL5773896

NC(=O)CC1CCN(Cc2cccnc2)CC1

nearest known ligand 0.58

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
VNN1 O95497 1/20 0.58
CACNA1I Q9P0X4 1/20 0.56
CHRNB2 P17787 1/20 0.56
CHRNA4 P43681 1/20 0.56
SIGMAR1 Q99720 1/20 0.55
KDM4E B2RXH2 2/20 0.54
KMT2A Q03164 1/20 0.53
PARP1 P09874 1/20 0.53
PARP2 Q9UGN5 1/20 0.53
ALDH1A1 P00352 2/20 0.51
CXCR4 P61073 1/20 0.51
DRD4 P21917 1/20 0.51
ACHE P22303 1/20 0.50
CHRM4 P08173 1/20 0.50
HTR4 Q13639 1/20 0.49
MAPT P10636 1/20 0.49
HTT P42858 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5771372 0.87 ACHE (0.58) CACNA1ICHRNB2CHRNA4SIGMAR1KDM4E
SCHEMBL2868175 0.86 SIGMAR1 (0.58) CACNA1ICHRNB2CHRNA4SIGMAR1KDM4E
SCHEMBL4379439 0.84 KMT2A (0.61) VNN1CACNA1ICHRNB2CHRNA4SIGMAR1
SCHEMBL4702875 0.83 SIGMAR1 (0.52) SIGMAR1KDM4EKMT2APARP1ALDH1A1
SCHEMBL4854037 0.83 GAA (0.64) CXCR4ACHE
SCHEMBL23028620 0.82 CHRNB2 (0.64) CACNA1ICHRNB2CHRNA4SIGMAR1KDM4E
Hydrochloric Acid SCHEMBL9538343 0.82 GAA (0.63) CXCR4ACHE
Hydrochloric Acid SCHEMBL9373038 0.82 GAA (0.63) CXCR4ACHE
SCHEMBL29508484 0.82 CHRNB2 (0.64) CACNA1ICHRNB2CHRNA4SIGMAR1KDM4E
SCHEMBL10041824 0.81 CHRNB2 (0.62) CHRNB2CHRNA4SIGMAR1KDM4EPARP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0931078-B1 NOVEL TRICYCLIC PIPERIDINYL COMPOUNDS USEFUL AS INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE SCHERING CORP (US) 2006-11-15 EP disclosed
CN-1237170-A Novel tricyclic piperidinyl compounds useful as inhibitors of farnesyl protein transferase SCHERING CORP (US) 1999-12-01 CN disclosed
US-5965570-A PHARMACEUTICAL COMPOSITIONS FOR INHIBITING THE ABNORMAL GROWTH OF CELLS; ADMINISTERING TO INHIBIT TUMOR CELLS WHEREIN THE RAS PROTEIN IS ACTIVATED AS A RESULT OF ONCOGENIC MUTATION IN GENES OTHER THAN THE RAS GENE SCHERING CORPORATION (US) 1999-10-12 US disclosed
EP-0931078-A1 NOVEL TRICYCLIC PIPERIDINYL COMPOUNDS USEFUL AS INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE SCHERING CORPORATION (US) 1999-07-28 EP disclosed
WO-1998011098-A1 NOVEL TRICYCLIC PIPERIDINYL COMPOUNDS USEFUL AS INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE SCHERING CORPORATION (US) 1998-03-19 WO disclosed