Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 9/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7225910 | 0.82 | CYP11B1 (0.39) | GAARAB9AMAPTPOLBKMT2A | |
| SCHEMBL5777872 | 0.75 | GAA (0.41) | GAARAB9AMAPTNPSR1JAK2 | |
| SCHEMBL946028 | 0.72 | LMNA (0.55) | GAARAB9AMAPTNPSR1JAK2 | |
| SCHEMBL3493043 | 0.71 | TSHR (0.44) | RAB9AMAPTLMNAMEN1KMT2A | |
| SCHEMBL3493650 | 0.71 | TSHR (0.44) | RAB9AMAPTLMNAMEN1KMT2A | |
| SCHEMBL6935703 | 0.71 | GAA (0.47) | GAARAB9AMAPTNPSR1JAK2 | |
| SCHEMBL6935698 | 0.71 | GAA (0.47) | GAARAB9AMAPTNPSR1JAK2 | |
| SCHEMBL2070179 | 0.70 | L3MBTL1 (0.45) | GAARAB9AMAPTNPSR1JAK2 | |
| SCHEMBL6935828 | 0.70 | GAA (0.46) | GAARAB9AMAPTNPSR1JAK2 | |
| SCHEMBL30437149 | 0.70 | GAA (0.46) | GAARAB9AMAPTNPSR1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1224189-B1 | CONDENSED DIHYDROQUINOLINONE DERIVATIVES FOR INHIBITING MRP1 | LILLY CO ELI (US) | 2006-01-25 | — | — | EP | disclosed |
| EP-1224189-A2 | CONDENSED DIHYDROQUINOLINONE DERIVATIVES FOR INHIBITING MRP1 | ELI LILLY AND COMPANY (US) | 2002-07-24 | — | — | EP | disclosed |
| WO-2001027116-A2 | CONDENSED DIHYDROQUINOLINONE DERIVATIVES FOR INHIBITING MRP1 | ELI LILLY AND COMPANY (US) | 2001-04-19 | — | — | WO | disclosed |