SCHEMBL5774967

SCHEMBL5774967

C#CCOc1cc(-c2ccc(C(F)(F)F)n(N)c2=O)c(F)cc1Cl

nearest known ligand 0.43

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.33
MEN1 O00255 1/20 0.32
XBP1 P17861 1/20 0.32
KMT2A Q03164 1/20 0.32
PGK1 P00558 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7682510 0.77 PGK1 (0.34) LMNAKMT2APGK1
SCHEMBL5773913 0.77 PGK1 (0.34) LMNAPGK1
SCHEMBL5775851 0.76 PGK1 (0.33) LMNAPGK1
SCHEMBL8187343 0.75 PGK1 (0.35) PGK1
SCHEMBL6937089 0.74 PGK1 (0.35) LMNAPGK1
SCHEMBL9185830 0.74 BCAT2 (0.35) LMNAPGK1
SCHEMBL5773940 0.71 IDH1 (0.32)
SCHEMBL5770809 0.70 IDH1 (0.33) KMT2A
SCHEMBL5770800 0.69 PTGS1 (0.38) LMNAMEN1XBP1KMT2A
SCHEMBL8192987 0.68 PGK1 (0.36) LMNAKMT2APGK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0885885-B1 PYRIDONE DERIVATIVES AND HERBICIDES KUMIAI CHEMICAL INDUSTRY CO (JP) 2006-01-04 EP disclosed
US-6472348-B1 Pyridone derivatives and herbicides KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 2002-10-29 US disclosed
US-6265349-B1 Pyridone derivatives and herbicides KUMIAI CHEMICAL INDUSTRY CO., LTD (JP) 2001-07-24 US disclosed
US-6048823-A Pyridone derivatives and herbicides KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 2000-04-11 US disclosed
EP-0885885-A1 PYRIDONE DERIVATIVES AND HERBICIDES KumaiI Chemical Industry Co., Ltd. (JP) 1998-12-23 EP disclosed