SCHEMBL5773913

SCHEMBL5773913

C#CCOc1cc(-c2c(Cl)cc(C(F)(F)F)n(C)c2=O)c(F)cc1Cl

nearest known ligand 0.43

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
PGK1 P00558 1/20 0.34
ITGB1 P05556 2/20 0.32
ITGA4 P13612 2/20 0.32
ITGB7 P26010 2/20 0.32
AGPAT2 O15120 1/20 0.31
EGFR P00533 1/20 0.31
LMNA P02545 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8187343 0.83 PGK1 (0.35) PGK1AGPAT2
SCHEMBL6937089 0.81 PGK1 (0.35) PGK1AGPAT2EGFRLMNA
SCHEMBL5775851 0.80 PGK1 (0.33) PGK1AGPAT2LMNA
SCHEMBL7682510 0.79 PGK1 (0.34) PGK1LMNA
SCHEMBL6937162 0.78 PGK1 (0.35) PGK1AGPAT2LMNA
SCHEMBL8192987 0.77 PGK1 (0.36) PGK1AGPAT2LMNA
SCHEMBL6936945 0.77 PGK1 (0.34) PGK1LMNA
SCHEMBL5774967 0.77 LMNA (0.33) PGK1LMNA
SCHEMBL6932316 0.77 PGK1 (0.34) PGK1LMNA
SCHEMBL6939644 0.76 PGK1 (0.35) PGK1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0885885-B1 PYRIDONE DERIVATIVES AND HERBICIDES KUMIAI CHEMICAL INDUSTRY CO (JP) 2006-01-04 EP disclosed
US-6472348-B1 Pyridone derivatives and herbicides KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 2002-10-29 US disclosed
US-6265349-B1 Pyridone derivatives and herbicides KUMIAI CHEMICAL INDUSTRY CO., LTD (JP) 2001-07-24 US disclosed
US-6048823-A Pyridone derivatives and herbicides KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 2000-04-11 US disclosed
EP-0885885-A1 PYRIDONE DERIVATIVES AND HERBICIDES KumaiI Chemical Industry Co., Ltd. (JP) 1998-12-23 EP disclosed