Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | ACHE | P22303 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | TAS2R14 | Q9NYV8 | 2/20 | 0.31 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
| ▸ | BMP1 | P13497 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5774835 | 0.89 | HTT (0.30) | KMT2AHTT | |
| SCHEMBL5771487 | 0.87 | KMT2A (0.33) | L3MBTL1KMT2AACHEHTTTAS2R14 | |
| SCHEMBL6199940 | 0.85 | PSEN1 (0.38) | L3MBTL1KMT2AHTT | |
| SCHEMBL1602478 | 0.85 | ALDH1A1 (0.38) | L3MBTL1KMT2AHTTTAS2R14MEN1 | |
| SCHEMBL6621241 | 0.81 | PDE4B (0.44) | — | |
| SCHEMBL1602317 | 0.77 | ABCB1 (0.47) | — | |
| SCHEMBL1600923 | 0.77 | ABCB1 (0.47) | — | |
| SCHEMBL1601957 | 0.77 | TP53 (0.39) | KMT2AHTTTAS2R14ALDH1A1GAA | |
| SCHEMBL1602845 | 0.75 | KMT2A (0.38) | KMT2AHTTTAS2R14ALDH1A1 | |
| SCHEMBL1602738 | 0.75 | BMP1 (0.38) | KMT2AHTTTAS2R14BMP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1637518-A2 | Inhibitors of aspartyl protease | Vertex Pharmaceuticals Incorporated (US) | 2006-03-22 | — | — | EP | disclosed |