SCHEMBL5776567

SCHEMBL5776567

CON(C)C(=O)c1ccc2ncn(C(=O)OC(C)(C)C)c2c1

nearest known ligand 0.41

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
GPR119 Q8TDV5 11/20 0.41
MLYCD O95822 1/20 0.37
KMT2A Q03164 3/20 0.37
AURKA O14965 1/20 0.36
CDK2 P24941 1/20 0.36
MEN1 O00255 1/20 0.34
GFER P55789 1/20 0.34
HTR6 P50406 1/20 0.34
FGFR1 P11362 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30962501 0.83 FGFR1 (0.50) KMT2AMEN1GFERFGFR1
SCHEMBL2143624 0.83 FGFR1 (0.50) KMT2AMEN1GFERFGFR1
SCHEMBL27472868 0.81 KMT2A (0.43) GPR119KMT2AAURKACDK2MEN1
SCHEMBL20239526 0.79 CHRNA7 (0.42) MLYCDKMT2AFGFR1
SCHEMBL29809047 0.79 CHRNA7 (0.42) MLYCDKMT2AFGFR1
SCHEMBL14852045 0.78 MAPT (0.44) GPR119KMT2AMEN1FGFR1
SCHEMBL832385 0.77 BRD4 (0.40) GPR119KMT2AMEN1GFER
SCHEMBL4816124 0.77 GABRG2 (0.47) KMT2AMEN1GFERHTR6
SCHEMBL7479053 0.77 HTR6 (0.44) KMT2AMEN1GFERHTR6FGFR1
SCHEMBL1417834 0.77 ACSS2 (0.46) GPR119KMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20060276433-A1 Hydrazone derivative DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2006-12-07 US disclosed
EP-1612204-A1 HYDRAZONE DERIVATIVE DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2006-01-04 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060276433-A1 Hydrazone derivative APP, PRNP, HTT GPR119 2675/4885MLYCD 3764/4885KMT2A 3533/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.