Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 2/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9806293 | 0.82 | ALDH1A1 (0.47) | ALDH1A1TSHRHTTCYP2C19HIF1A | |
| SCHEMBL245863 | 0.81 | CYP2C19 (0.58) | ALDH1A1TSHRCYP2C19HIF1AMAPT | |
| SCHEMBL13126929 | 0.81 | ALDH1A1 (0.46) | ALDH1A1TSHRHTTCYP2C19HIF1A | |
| Acrylic Acid SCHEMBL1724043 | 0.79 | CYP2C19 (0.53) | ALDH1A1TSHRHTTCYP2C19HIF1A | |
| SCHEMBL11013243 | 0.79 | CYP2C19 (0.44) | ALDH1A1TSHRHTTCYP2C19HIF1A | |
| SCHEMBL11013263 | 0.79 | CYP2C19 (0.44) | ALDH1A1TSHRHTTCYP2C19HIF1A | |
| SCHEMBL5777855 | 0.78 | ALDH1A1 (0.43) | ALDH1A1TSHRHTTCYP2C19HIF1A | |
| SCHEMBL17120416 | 0.78 | TSHR (0.43) | ALDH1A1TSHRHTTCYP2C19HIF1A | |
| SCHEMBL335125 | 0.76 | ALDH1A1 (0.53) | ALDH1A1TSHRHTTCYP2C19HIF1A | |
| SCHEMBL15242554 | 0.76 | ALDH1A1 (0.53) | ALDH1A1TSHRHTTCYP2C19HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8741897-B2 | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2014-06-03 | — | — | US | disclosed |
| US-8741897-B2 | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2014-06-03 | — | — | US | disclosed |
| US-8741897-B2 | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2014-06-03 | — | — | US | disclosed |
| EP-1673088-A1 | 1,1,1- TRIFLUORO-4-PHENYL-4-METHYL-2-(1H-PYRROLO¬2,3-C|PYRIDIN-2-YLMETHYL)PENTAN-2-OL DERIVATIVES AND RELATED COMPOUNDS AS GLUCOCORTICOID LIGANDS FOR THE TREATMENT OF INFLAMMATORY DISEASES AND DIABETES | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2006-06-28 | — | — | EP | disclosed |
| US-20050176706-A1 | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2005-08-11 | — | — | US | disclosed |
| WO-2005030213-A1 | 1,1,1-TRIFLUORO-4-PHENYL-4-METHYL-2-(1H-PYRROLO | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2005-04-07 | — | — | WO | disclosed |
| US-4549029-A | ORGANOLEPTIC | GIVAUDAN CORPORATION (US) | 1985-10-22 | — | — | US | disclosed |
| EP-0049543-B1 | PERFUME COMPOSITIONS AND PERFUMED MATERIALS AND ARTICLES, CONTAINING PHENYL-TETRAHYDROFURANS AS A FRAGRANCE | NAARDEN INTERNATIONAL N.V. (NL) | 1985-03-20 | — | — | EP | disclosed |
| US-4404127-A | SOAPS; CLEANING COMPOUNDS; COSMETICS; DETERGENTS; OXIDATION RESISTANCE | NAARDEN INTERNATIONAL N.V. (NL) | 1983-09-13 | — | — | US | disclosed |
| EP-0049543-A1 | Perfume compositions and perfumed materials and articles, containing phenyl-tetrahydrofurans as a fragrance | NAARDEN INTERNATIONAL N.V. (NL) | 1982-04-14 | — | — | EP | disclosed |
| EP-0049545-A1 | High-pressure mercury vapour discharge lamp | Koninklijke Philips Electronics N.V. (NL) | 1982-04-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050176706-A1 | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof | NR3C1, NR3C2, MC2R | ALDH1A1 3621/4885TSHR 229/4885HTT 1629/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.