Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 4/20 | 0.41 |
| ▸ | CDK6 | Q00534 | 3/20 | 0.41 |
| ▸ | GSK3B | P49841 | 3/20 | 0.40 |
| ▸ | CCND1 | P24385 | 1/20 | 0.40 |
| ▸ | CCND2 | P30279 | 1/20 | 0.40 |
| ▸ | CCND3 | P30281 | 1/20 | 0.40 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.36 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.36 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.36 |
| ▸ | REN | P00797 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | LATS1 | O95835 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8362929 | 0.78 | PIK3CA (0.44) | CDK4CDK6GSK3BCCND1CCND2 | |
| SCHEMBL5872050 | 0.77 | GAA (0.44) | CDK4GSK3BCCND1CCND2CCND3 | |
| SCHEMBL8287197 | 0.77 | EGFR (0.43) | CDK4GSK3BCCND1CCND2CCND3 | |
| SCHEMBL5871843 | 0.77 | MAT2A (0.40) | CDK4GSK3BCCND1CCND2CCND3 | |
| SCHEMBL8285278 | 0.76 | MAPK1 (0.38) | CDK4GSK3BCCND1CCND2CCND3 | |
| SCHEMBL8287560 | 0.76 | EGFR (0.37) | CDK4GSK3BCCND1CCND2CCND3 | |
| SCHEMBL8285286 | 0.76 | GRM5 (0.36) | CDK4CDK6GSK3BCCND1CCND2 | |
| SCHEMBL8287246 | 0.75 | GAA (0.39) | CDK4GSK3BCCND1CCND2CCND3 | |
| SCHEMBL8287196 | 0.75 | GSK3B (0.37) | CDK4CDK6GSK3BCCND1CCND2 | |
| SCHEMBL8287593 | 0.75 | GSK3B (0.37) | CDK4GSK3BCCND1CCND2CCND3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1513840-B1 | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF DIABETES AND DIABETES-RELATED DISORDERS | BAYER PHARMACEUTICALS CORP (US) | 2006-10-04 | — | — | EP | disclosed |
| US-20060009483-A1 | Compounds and compositions for the treatment of diabetes and diabetes-related disorders | BAYER PHARMACEUTICALS CORPORATION (US) | 2006-01-12 | — | — | US | disclosed |
| EP-1513840-A2 | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF DIABETES AND DIABETES-RELATED DISORDERS | Bayer Pharmaceuticals Corporation (US) | 2005-03-16 | — | — | EP | disclosed |
| WO-2003101988-A2 | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF DIABETES AND DIABETES-RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-12-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060009483-A1 | Compounds and compositions for the treatment of diabetes and diabetes-related disorders | IAPP, GPR119, PNLIP | CDK4 1095/4885CDK6 1002/4885GSK3B 857/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.