Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXA2R | P21731 | 11/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.31 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5773541 | 0.86 | TBXA2R (0.55) | TBXA2RPTGDR2AKR1B1 | |
| SCHEMBL5777733 | 0.78 | TBXA2R (0.42) | TBXA2RPTGDR2 | |
| SCHEMBL5776946 | 0.77 | TBXA2R (0.45) | TBXA2R | |
| SCHEMBL5776538 | 0.76 | TBXA2R (0.39) | TBXA2RPTGDR2AKR1B1 | |
| SCHEMBL5777618 | 0.71 | TBXA2R (0.79) | TBXA2RPTGDR2 | |
| SCHEMBL5835634 | 0.70 | TBXA2R (0.56) | TBXA2RPTGDR2 | |
| SCHEMBL5775601 | 0.69 | TBXA2R (0.45) | TBXA2RPTGDR2AKR1B1CYP2C9 | |
| SCHEMBL5777307 | 0.68 | TBXA2R (0.32) | TBXA2RPTGDR2AKR1B1CYP2C9 | |
| SCHEMBL5773536 | 0.64 | TBXA2R (0.56) | TBXA2RPTGDR2AKR1B1 | |
| SCHEMBL5779000 | 0.62 | TBXA2R (0.55) | TBXA2RPTGDR2AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1395590-B1 | DIHYDROPYRROLO¬1,2-A|INDOLE AND TETRAHYDROPYRIDO¬1,2-A|INDOLE DERIVATIVES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS | MERCK FROSST CANADA INC (CA) | 2006-09-27 | — | — | EP | disclosed |