Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 11/20 | 0.91 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.91 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.91 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.71 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.71 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.71 |
| ▸ | DRD4 | P21917 | 3/20 | 0.68 |
| ▸ | DRD2 | P14416 | 2/20 | 0.68 |
| ▸ | DRD3 | P35462 | 2/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.68 |
| ▸ | AKT1 | P31749 | 1/20 | 0.67 |
| ▸ | AKT2 | P31751 | 1/20 | 0.67 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3665096 | 0.95 | OPRM1 (1.00) | OPRM1OPRK1OPRL1DRD4DRD2 | |
| SCHEMBL8863557 | 0.91 | OPRM1 (0.91) | OPRM1OPRK1OPRL1DRD4DRD2 | |
| SCHEMBL1436457 | 0.89 | OPRM1 (0.79) | OPRM1OPRK1OPRL1DRD4CYP3A4 | |
| SCHEMBL11223608 | 0.88 | OPRM1 (0.86) | OPRM1OPRK1OPRL1DRD4AKT1 | |
| Oxalic Acid SCHEMBL5772739 | 0.87 | KDM4E (0.79) | OPRM1OPRK1OPRL1KDM4EALDH1A1 | |
| SCHEMBL3634015 | 0.86 | OPRM1 (0.83) | OPRM1OPRK1OPRL1DRD4DRD2 | |
| SCHEMBL20763210 | 0.86 | OPRM1 (1.00) | OPRM1OPRK1OPRL1DRD4DRD2 | |
| SCHEMBL12375874 | 0.85 | OPRM1 (0.77) | OPRM1OPRK1OPRL1DRD4DRD2 | |
| SCHEMBL3666414 | 0.85 | OPRM1 (0.72) | OPRM1OPRK1OPRL1DRD4CYP3A4 | |
| SCHEMBL5848837 | 0.84 | OPRM1 (0.71) | OPRM1OPRK1OPRL1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0898568-B1 | 1-(4-PIPERIDYL)-BENZIMIDAZOLES HAVING NEUROTROPHIC ACTIVITY | NEUROSEARCH AS (DK) | 2006-10-04 | — | — | EP | disclosed |
| US-6180649-B1 | NERVOUS SYSTEM DISORDERS; ALZHEIMER'S, HUNTINGTON, PARKINSON DISEASE | NEROSEARCH A/S (DK) | 2001-01-30 | — | — | US | disclosed |
| EP-0898568-A1 | 1-(4-PIPERIDYL)-BENZIMIDAZOLES HAVING NEUROTROPHIC ACTIVITY | NEUROSEARCH A/S (DK) | 1999-03-03 | — | — | EP | disclosed |
| WO-1997040035-A1 | 1-(4-PIPERIDYL)-BENZIMIDAZOLES HAVING NEUROTROPHIC ACTIVITY | NEUROSEARCH A/S (DK) | 1997-10-30 | — | — | WO | disclosed |