Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 7/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.79 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.79 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.79 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.69 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.69 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.68 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.68 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.66 |
| ▸ | DRD2 | P14416 | 4/20 | 0.63 |
| ▸ | DRD4 | P21917 | 3/20 | 0.63 |
| ▸ | DRD3 | P35462 | 3/20 | 0.63 |
| ▸ | PLD2 | O14939 | 1/20 | 0.63 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.61 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.61 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.61 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.61 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.61 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7963223 | 0.94 | CYP2D6 (0.77) | KDM4EALDH1A1PMP22NPSR1CYP2D6 | |
| Oxalic Acid SCHEMBL5772154 | 0.89 | KDM4E (1.00) | KDM4EALDH1A1PMP22NPSR1CYP2D6 | |
| Oxalic Acid SCHEMBL5778025 | 0.87 | OPRM1 (0.91) | KDM4EALDH1A1PMP22NPSR1OPRM1 | |
| Oxalic Acid SCHEMBL5807061 | 0.87 | KDM4E (0.92) | KDM4EALDH1A1PMP22NPSR1CYP2D6 | |
| Oxalic Acid SCHEMBL5777428 | 0.87 | KDM4E (0.92) | KDM4EALDH1A1PMP22NPSR1CYP2D6 | |
| SCHEMBL5848837 | 0.85 | OPRM1 (0.71) | KDM4EALDH1A1PMP22NPSR1CYP2D6 | |
| SCHEMBL28539041 | 0.84 | CYP2D6 (0.86) | KDM4EALDH1A1PMP22NPSR1CYP2D6 | |
| SCHEMBL6404540 | 0.83 | PLD1 (0.81) | KDM4EALDH1A1PMP22NPSR1CYP2D6 | |
| SCHEMBL5777516 | 0.82 | PLD2 (0.68) | KDM4EALDH1A1PMP22NPSR1CYP2D6 | |
| SCHEMBL22587867 | 0.81 | CHRM1 (0.69) | KDM4EALDH1A1PMP22NPSR1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0898568-B1 | 1-(4-PIPERIDYL)-BENZIMIDAZOLES HAVING NEUROTROPHIC ACTIVITY | NEUROSEARCH AS (DK) | 2006-10-04 | — | — | EP | disclosed |
| US-6180649-B1 | NERVOUS SYSTEM DISORDERS; ALZHEIMER'S, HUNTINGTON, PARKINSON DISEASE | NEROSEARCH A/S (DK) | 2001-01-30 | — | — | US | disclosed |
| EP-0898568-A1 | 1-(4-PIPERIDYL)-BENZIMIDAZOLES HAVING NEUROTROPHIC ACTIVITY | NEUROSEARCH A/S (DK) | 1999-03-03 | — | — | EP | disclosed |
| WO-1997040035-A1 | 1-(4-PIPERIDYL)-BENZIMIDAZOLES HAVING NEUROTROPHIC ACTIVITY | NEUROSEARCH A/S (DK) | 1997-10-30 | — | — | WO | disclosed |