Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.56 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 5/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.51 |
| ▸ | ACHE | P22303 | 1/20 | 0.51 |
| ▸ | DRD4 | P21917 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4506302 | 0.94 | POLB (0.65) | POLBNPBWR1MCHR1MAPTALDH1A1 | |
| SCHEMBL4493810 | 0.88 | MAPT (0.66) | MAPTALDH1A1LMNASMN1; SMN2ALOX12 | |
| SCHEMBL6702413 | 0.87 | ALDH1A1 (0.60) | POLBMAPTALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL31349281 | 0.82 | ALDH1A1 (0.74) | POLBMAPTALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL1126947 | 0.82 | POLB (0.75) | POLBNPBWR1MCHR1MAPTALDH1A1 | |
| SCHEMBL15347670 | 0.81 | POLB (0.73) | POLBNPBWR1MCHR1MAPTALDH1A1 | |
| SCHEMBL5540751 | 0.78 | SIGMAR1 (0.65) | MAPTALDH1A1LMNAKDM4ESIGMAR1 | |
| SCHEMBL5206645 | 0.77 | POLB (0.68) | POLBNPBWR1MCHR1MAPTALDH1A1 | |
| SCHEMBL16299053 | 0.77 | ALDH1A1 (0.74) | POLBMAPTALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL6695285 | 0.77 | KCNJ1 (0.65) | POLBMAPTALDH1A1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682531-A2 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005042518-A2 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2005-05-12 | — | — | WO | disclosed |