Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HTM | Q9NXG6 | 4/20 | 0.52 |
| ▸ | HPGDS | O60760 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KDM6B | O15054 | 1/20 | 0.38 |
| ▸ | KDM4A | O75164 | 1/20 | 0.38 |
| ▸ | KDM5C | P41229 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL992708 | 0.79 | KMT2A (0.56) | P4HTMKDM4ERAB9ALMNANPC1 | |
| SCHEMBL2504660 | 0.77 | ALDH1A1 (0.54) | KDM4ELMNAALDH1A1L3MBTL1KMT2A | |
| SCHEMBL133554 | 0.76 | KMT2A (0.53) | RAB9ALMNANPC1ALDH1A1TP53 | |
| SCHEMBL19309377 | 0.76 | KMT2A (0.53) | RAB9ALMNANPC1ALDH1A1TP53 | |
| SCHEMBL16938414 | 0.76 | GABRP (0.49) | KDM4EHPGDRAB9ANPC1ALDH1A1 | |
| SCHEMBL27076571 | 0.76 | MAPK1 (0.38) | KDM4ERAB9ANPC1L3MBTL1KMT2A | |
| SCHEMBL4758814 | 0.76 | HDAC1 (0.45) | KDM4ERAB9ANPC1ALDH1A1L3MBTL1 | |
| SCHEMBL15498446 | 0.76 | P4HTM (0.62) | P4HTMHPGDSKDM4EALOX15RAB9A | |
| SCHEMBL3688798 | 0.75 | HRH3 (0.50) | HPGDSHTTSMN1; SMN2 | |
| SCHEMBL1509187 | 0.75 | MAPK1 (0.41) | KDM4ERAB9ANPC1L3MBTL1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1644372-A2 | SUBSTITUTED QUINOLIN-4-YLAMINE ANALOGUES | NEUROGEN CORPORATION (US) | 2006-04-12 | — | — | EP | disclosed |
| WO-2005007652-A2 | SUBSTITUTED QUINOLIN-4-YLAMINE ANALOGUES | NEUROGEN CORPORATION (US) | 2005-01-27 | — | — | WO | disclosed |