Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | CASP6 | P55212 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | MGLL | Q99685 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | VDR | P11473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21473610 | 0.77 | NPC1 (0.69) | MEN1KMT2AGAACASP6MAPT | |
| SCHEMBL29836323 | 0.73 | GRIN2D (0.57) | MEN1KMT2AMAPTALDH1A1ADRB1 | |
| SCHEMBL28454067 | 0.73 | GRIN2D (0.57) | MEN1KMT2AMAPTALDH1A1ADRB1 | |
| SCHEMBL13309243 | 0.73 | VDR (0.60) | MEN1KMT2AGAACASP6MAPT | |
| SCHEMBL19480168 | 0.71 | GAA (0.47) | MEN1KMT2AGAACASP6MAPT | |
| SCHEMBL7810597 | 0.70 | KMT2A (0.46) | KMT2AALDH1A1L3MBTL1NPC1RAB9A | |
| SCHEMBL25472677 | 0.70 | NPC1 (0.44) | MEN1KMT2AGAACASP6MAPT | |
| SCHEMBL25138674 | 0.69 | MAPT (1.00) | MEN1KMT2AGAAMAPTALDH1A1 | |
| SCHEMBL15307676 | 0.69 | VDR (0.49) | MEN1KMT2AGAACASP6MAPT | |
| SCHEMBL10373770 | 0.68 | ADRB1 (0.74) | MAPTALDH1A1L3MBTL1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1558260-A4 | QUINAZOLINONE COMPOUNDS AS CALCILYTICS | NPS PHARMA INC (US) | 2006-10-25 | — | — | EP | disclosed |
| EP-1558260-A2 | QUINAZOLINONE COMPOUNDS AS CALCILYTICS | NPS PHARMACEUTICALS, INC. (US) | 2005-08-03 | — | — | EP | disclosed |
| WO-2004041755-A2 | QUINAZOLINONE COMPOUNDS AS CALCILYTICS | NPS PHARMACEUTICALS, INC. (US) | 2004-05-21 | — | — | WO | disclosed |