Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.54 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | HRH2 | P25021 | 1/20 | 0.51 |
| ▸ | HRH1 | P35367 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4167205 | 0.85 | PSMB1 (0.60) | KDM4EHRH3 | |
| SCHEMBL5782622 | 0.84 | SIGMAR1 (0.70) | SIGMAR1KDM4ERECQLTDP1HRH3 | |
| SCHEMBL11881843 | 0.82 | HRH3 (0.64) | SIGMAR1KDM4ERECQLTDP1HRH3 | |
| SCHEMBL11880951 | 0.82 | SIGMAR1 (0.63) | SIGMAR1KDM4ERECQLTDP1HRH3 | |
| SCHEMBL5785769 | 0.82 | GAA (0.60) | SIGMAR1KDM4EHRH3SMN1; SMN2 | |
| SCHEMBL19234679 | 0.81 | SIGMAR1 (0.73) | SIGMAR1KDM4ERECQLTDP1HRH3 | |
| SCHEMBL9940278 | 0.80 | SIGMAR1 (0.68) | SIGMAR1KDM4EKMT2ARECQLTDP1 | |
| SCHEMBL23366756 | 0.80 | SIGMAR1 (0.71) | SIGMAR1KDM4ERECQLTDP1HRH3 | |
| SCHEMBL4484351 | 0.80 | SIGMAR1 (0.71) | SIGMAR1KDM4ERECQLTDP1HRH3 | |
| SCHEMBL3866360 | 0.80 | SIGMAR1 (0.71) | SIGMAR1KDM4EKMT2ARECQLTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1708698-A1 | 3-(4-PIPERIDINE-1YLMETHYL-PHENYL)-PROPION ACID-PHENYLAMIDE-DERIVATIVES AND RELATED COMPOUNDS USED IN THE FORM OF MCH ANTAGONISTS (MELANINE CONCENTRATING HORMONE) FOR TREATING EATING DISORDERS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2006-10-11 | — | — | EP | disclosed |
| WO-2005063239-A9 | 3-(4-PIPERIDINE-1YLMETHYL-PHENYL)-PROPION ACID-PHENYLAMIDE-DERIVATIVES AND RELATED COMPOUNDS USED IN THE FORM OF MCH ANTAGONISTS (MELANINE CONCENTRATING HORMONE) FOR TREATING EATING DISORDERS | BOEHRINGER INGELHEIM INT (DE) | 2006-03-09 | — | — | WO | disclosed |
| WO-2005063239-A1 | 3-(4-PIPERIDINE-1YLMETHYL-PHENYL)-PROPION ACID-PHENYLAMIDE-DERIVATIVES AND RELATED COMPOUNDS USED IN THE FORM OF MCH ANTAGONISTS (MELANINE CONCENTRATING HORMONE) FOR TREATING EATING DISORDERS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-07-14 | — | — | WO | disclosed |