Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | MPO | P05164 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5437258 | 0.91 | KDM4E (0.49) | KDM4ECYP3A4CYP2C19HIF1APOLB | |
| SCHEMBL5440887 | 0.91 | MPO (0.46) | KDM4EPOLBKMT2AMEN1MAPT | |
| SCHEMBL5798135 | 0.79 | KDM4E (0.49) | KDM4ECYP2C19POLBKMT2AMEN1 | |
| SCHEMBL5434270 | 0.77 | KDM4E (0.50) | KDM4ECYP3A4CYP2C19HIF1APOLB | |
| SCHEMBL2534941 | 0.77 | KDM4E (0.62) | KDM4ECYP3A4CYP2C19HIF1AMAPT | |
| SCHEMBL3420261 | 0.73 | POLB (0.52) | KDM4ECYP3A4CYP2C19HIF1APOLB | |
| SCHEMBL13802956 | 0.73 | KDM4E (0.54) | KDM4EPOLBKMT2AMAPTLMNA | |
| SCHEMBL8936155 | 0.73 | POLB (0.72) | KDM4ECYP3A4CYP2C19HIF1APOLB | |
| SCHEMBL23202854 | 0.73 | ACHE (0.42) | KDM4EKMT2AMEN1MAPTMPO | |
| SCHEMBL14960133 | 0.73 | POLB (0.61) | KDM4ECYP3A4CYP2C19POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1706384-A1 | THERAPEUTIC AGENTS I | AstraZeneca AB (SE) | 2006-10-04 | — | — | EP | disclosed |
| WO-2005066132-A1 | THERAPEUTIC AGENTS I | ASTRAZENECA AB (SE) | 2005-07-21 | — | — | WO | disclosed |